Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans
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Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 103791 |
| Tidsskrift | iScience |
| Vol/bind | 25 |
| Udgave nummer | 2 |
| Antal sider | 18 |
| ISSN | 2589-0042 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
We thank members of Pocock laboratory and Brent Neumann for comments on the manuscript. Some strains used in this study were provided by the Caenorhabditis Genetics Center, which is funded by NIH Office of Research Infrastructure Programs ( P40 OD010440 ), and by Shohei Mitani at the National Bioresource Project (Japan). We also thank Rick Padgett for the elt-3p::sma-6::gfp plasmid, Jun Liu for the Myc-SMA-6 plasmid, Yuichi Iino for the rimb-1 promoter, and Yun Zhang for the sma-6(wk7); ges-1p::sma-6, and sma-6(wk7); sma-6p::sma-6 rescue strains. The authors also acknowledge use of the services and facilities of Micromon Genomics at Monash University . Funding: This work was supported by a grant from the European Research Council (ERC Starting Grant number 260807 ), Monash Biomedicine Discovery Fellowship , NHMRC Project Grant ( GNT1105374 ), NHMRC Senior Research Fellowship ( GNT1137645 ), and a Victorian Endowment for Science, Knowledge and Innovation Fellowship ( VIF23 ) to R.P.
Publisher Copyright:
© 2022 The Author(s)
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