Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

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Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans. / Baltaci, Oguzhan; Pedersen, Mikael Egebjerg; Sherry, Tessa; Handley, Ava; Snieckute, Goda; Cao, Wei; Haas, Matilda; Archer, Stuart; Pocock, Roger.

I: iScience, Bind 25, Nr. 2, 103791, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Baltaci, O, Pedersen, ME, Sherry, T, Handley, A, Snieckute, G, Cao, W, Haas, M, Archer, S & Pocock, R 2022, 'Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans', iScience, bind 25, nr. 2, 103791. https://doi.org/10.1016/j.isci.2022.103791

APA

Baltaci, O., Pedersen, M. E., Sherry, T., Handley, A., Snieckute, G., Cao, W., Haas, M., Archer, S., & Pocock, R. (2022). Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans. iScience, 25(2), [103791]. https://doi.org/10.1016/j.isci.2022.103791

Vancouver

Baltaci O, Pedersen ME, Sherry T, Handley A, Snieckute G, Cao W o.a. Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans. iScience. 2022;25(2). 103791. https://doi.org/10.1016/j.isci.2022.103791

Author

Baltaci, Oguzhan ; Pedersen, Mikael Egebjerg ; Sherry, Tessa ; Handley, Ava ; Snieckute, Goda ; Cao, Wei ; Haas, Matilda ; Archer, Stuart ; Pocock, Roger. / Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans. I: iScience. 2022 ; Bind 25, Nr. 2.

Bibtex

@article{49ef9e8a5d4e4d00af43e49cfec7cbf3,
title = "Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans",
abstract = "Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.",
keywords = "Biological sciences, Developmental neuroscience, Molecular neuroscience",
author = "Oguzhan Baltaci and Pedersen, {Mikael Egebjerg} and Tessa Sherry and Ava Handley and Goda Snieckute and Wei Cao and Matilda Haas and Stuart Archer and Roger Pocock",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
doi = "10.1016/j.isci.2022.103791",
language = "English",
volume = "25",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans

AU - Baltaci, Oguzhan

AU - Pedersen, Mikael Egebjerg

AU - Sherry, Tessa

AU - Handley, Ava

AU - Snieckute, Goda

AU - Cao, Wei

AU - Haas, Matilda

AU - Archer, Stuart

AU - Pocock, Roger

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.

AB - Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming growth factor β (TGF-β) type I receptor SMA-6 (small-6) acts independently of its cognate TGF-β type II receptor DAF-4 (dauer formation-defective-4) to control neuronal guidance. SMA-6 directs neuronal development from the hypodermis through interactions with three, orphan, TGF-β ligands. Intracellular signaling downstream of SMA-6 limits expression of NLR-1, an essential Neurexin-like cell adhesion receptor, to enable neuronal guidance. Together, our data identify an atypical TGF-β-mediated regulatory mechanism to ensure correct neuronal development.

KW - Biological sciences

KW - Developmental neuroscience

KW - Molecular neuroscience

U2 - 10.1016/j.isci.2022.103791

DO - 10.1016/j.isci.2022.103791

M3 - Journal article

C2 - 35146399

AN - SCOPUS:85123846562

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 2

M1 - 103791

ER -

ID: 345417875