TY - JOUR

T1 - The dawn of the functional genomics era in muscle physiology

AU - Seaborne, Robert A.E.

AU - Ochala, Julien

N1 - Funding Information: No independent funding was sourced or used for the production of this work. The authors would like to thank all the cited works for their developments within the respective fields and to acknowledge those unable to be cited due to space requirements. We also acknowledge BioRender (https://biorender.com) for the generation of all figures. Publisher Copyright: © 2023 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.

PY - 2023/4/15

Y1 - 2023/4/15

N2 - Skeletal muscle is the most abundant component of the mature mammalian phenotype. Designed to generate contractile force and movement, skeletal muscle is crucial for organism health, function and development. One of the great interests for muscle biologists is in understanding how skeletal muscle adapts during periods of stress and stimuli, such as disease, disuse and ageing. To this end, genomic-based experimental and analytical approaches offer one of the most powerful approaches for comprehensively mapping the molecular paradigms that regulate skeletal muscle. With the power, applicability, and robustness of ‘omic’ technologies continually being developed, we are now in a position to investigate these molecular mechanisms in skeletal muscle to an unprecedented level of accuracy and precision, heralding the dawn of a new era of functional genomics in the field of muscle physiology. (Figure presented.).

AB - Skeletal muscle is the most abundant component of the mature mammalian phenotype. Designed to generate contractile force and movement, skeletal muscle is crucial for organism health, function and development. One of the great interests for muscle biologists is in understanding how skeletal muscle adapts during periods of stress and stimuli, such as disease, disuse and ageing. To this end, genomic-based experimental and analytical approaches offer one of the most powerful approaches for comprehensively mapping the molecular paradigms that regulate skeletal muscle. With the power, applicability, and robustness of ‘omic’ technologies continually being developed, we are now in a position to investigate these molecular mechanisms in skeletal muscle to an unprecedented level of accuracy and precision, heralding the dawn of a new era of functional genomics in the field of muscle physiology. (Figure presented.).

KW - genomics

KW - molecular physiology

KW - skeletal muscle

U2 - 10.1113/JP284206

DO - 10.1113/JP284206

M3 - Review

C2 - 36829294

AN - SCOPUS:85150589970

VL - 601

SP - 1343

EP - 1352

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - 8

ER -