TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis. / Tulstrup, Morten; Soerensen, Mette; Hansen, Jakob Werner; Gillberg, Linn; Needhamsen, Maria; Kaastrup, Katja; Helin, Kristian; Christensen, Kaare; Weischenfeldt, Joachim; Grønbæk, Kirsten.

I: Nature Communications, Bind 12, Nr. 1, 6061, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tulstrup, M, Soerensen, M, Hansen, JW, Gillberg, L, Needhamsen, M, Kaastrup, K, Helin, K, Christensen, K, Weischenfeldt, J & Grønbæk, K 2021, 'TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis', Nature Communications, bind 12, nr. 1, 6061. https://doi.org/10.1038/s41467-021-26093-2

APA

Tulstrup, M., Soerensen, M., Hansen, J. W., Gillberg, L., Needhamsen, M., Kaastrup, K., Helin, K., Christensen, K., Weischenfeldt, J., & Grønbæk, K. (2021). TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis. Nature Communications, 12(1), [6061]. https://doi.org/10.1038/s41467-021-26093-2

Vancouver

Tulstrup M, Soerensen M, Hansen JW, Gillberg L, Needhamsen M, Kaastrup K o.a. TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis. Nature Communications. 2021;12(1). 6061. https://doi.org/10.1038/s41467-021-26093-2

Author

Tulstrup, Morten ; Soerensen, Mette ; Hansen, Jakob Werner ; Gillberg, Linn ; Needhamsen, Maria ; Kaastrup, Katja ; Helin, Kristian ; Christensen, Kaare ; Weischenfeldt, Joachim ; Grønbæk, Kirsten. / TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis. I: Nature Communications. 2021 ; Bind 12, Nr. 1.

Bibtex

@article{7eb38f7f345f445c94c12717ccc8c7af,
title = "TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis",
abstract = "Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS). Here, we investigate associations between TET2 mutations and DNA methylation in whole blood in 305 elderly twins, 15 patients with CCUS and 18 healthy controls. We find that TET2 mutations are associated with DNA hypermethylation at enhancer sites in whole blood in CHIP and in both granulocytes and mononuclear cells in CCUS. These hypermethylated sites are associated with leukocyte function and immune response and ETS-related and C/EBP-related transcription factor motifs. While the majority of TET2-associated hypermethylation sites are shared between CHIP and in AML, we find a set of AML-specific hypermethylated loci at active enhancer elements in hematopoietic stem cells. In summary, we show that TET2 mutations is associated with hypermethylated enhancers involved in myeloid differentiation in both CHIP, CCUS and AML patients.",
author = "Morten Tulstrup and Mette Soerensen and Hansen, {Jakob Werner} and Linn Gillberg and Maria Needhamsen and Katja Kaastrup and Kristian Helin and Kaare Christensen and Joachim Weischenfeldt and Kirsten Gr{\o}nb{\ae}k",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
doi = "10.1038/s41467-021-26093-2",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis

AU - Tulstrup, Morten

AU - Soerensen, Mette

AU - Hansen, Jakob Werner

AU - Gillberg, Linn

AU - Needhamsen, Maria

AU - Kaastrup, Katja

AU - Helin, Kristian

AU - Christensen, Kaare

AU - Weischenfeldt, Joachim

AU - Grønbæk, Kirsten

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2021

Y1 - 2021

N2 - Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS). Here, we investigate associations between TET2 mutations and DNA methylation in whole blood in 305 elderly twins, 15 patients with CCUS and 18 healthy controls. We find that TET2 mutations are associated with DNA hypermethylation at enhancer sites in whole blood in CHIP and in both granulocytes and mononuclear cells in CCUS. These hypermethylated sites are associated with leukocyte function and immune response and ETS-related and C/EBP-related transcription factor motifs. While the majority of TET2-associated hypermethylation sites are shared between CHIP and in AML, we find a set of AML-specific hypermethylated loci at active enhancer elements in hematopoietic stem cells. In summary, we show that TET2 mutations is associated with hypermethylated enhancers involved in myeloid differentiation in both CHIP, CCUS and AML patients.

AB - Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined significance (CCUS). Here, we investigate associations between TET2 mutations and DNA methylation in whole blood in 305 elderly twins, 15 patients with CCUS and 18 healthy controls. We find that TET2 mutations are associated with DNA hypermethylation at enhancer sites in whole blood in CHIP and in both granulocytes and mononuclear cells in CCUS. These hypermethylated sites are associated with leukocyte function and immune response and ETS-related and C/EBP-related transcription factor motifs. While the majority of TET2-associated hypermethylation sites are shared between CHIP and in AML, we find a set of AML-specific hypermethylated loci at active enhancer elements in hematopoietic stem cells. In summary, we show that TET2 mutations is associated with hypermethylated enhancers involved in myeloid differentiation in both CHIP, CCUS and AML patients.

U2 - 10.1038/s41467-021-26093-2

DO - 10.1038/s41467-021-26093-2

M3 - Journal article

C2 - 34663818

AN - SCOPUS:85117470146

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 6061

ER -

ID: 282741750