Single-Voxel MR Spectroscopy of Gliomas with s-LASER at 7T
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Single-Voxel MR Spectroscopy of Gliomas with s-LASER at 7T. / Prener, Martin; Opheim, Giske; Shams, Zahra; Søndergaard, Christian Baastrup; Lindberg, Ulrich; Larsson, Henrik B W; Ziebell, Morten; Larsen, Vibeke Andrée; Vestergaard, Mark Bitsch; Paulson, Olaf B.
I: Diagnostics, Bind 13, Nr. 10, 1805, 19.05.2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Single-Voxel MR Spectroscopy of Gliomas with s-LASER at 7T
AU - Prener, Martin
AU - Opheim, Giske
AU - Shams, Zahra
AU - Søndergaard, Christian Baastrup
AU - Lindberg, Ulrich
AU - Larsson, Henrik B W
AU - Ziebell, Morten
AU - Larsen, Vibeke Andrée
AU - Vestergaard, Mark Bitsch
AU - Paulson, Olaf B
PY - 2023/5/19
Y1 - 2023/5/19
N2 - BACKGROUND AND PURPOSE: Magnetic resonance spectroscopy (MRS)-a method of analysing metabolites in vivo-has been utilized in several studies of brain glioma biomarkers at lower field strengths. At ultra-high field strengths, MRS provides an improved signal-to-noise-ratio and spectral resolution, but 7T studies on patients with gliomas are sparse. The purpose of this exploratory study was to evaluate the potential clinical implication of the use of single-voxel MRS at 7T to assess metabolic information on lesions in a pilot cohort of patients with grade II and III gliomas.METHODS: We scanned seven patients and seven healthy controls using the semi-localization by adiabatic-selective refocusing sequence on a Philips Achieva 7T system with a standard dual-transmit head coil. The metabolic ratios were calculated relative to water and total creatine. Additionally, 2-hydroxyglutarate (2-HG) MRS was carried out in four of the patients, and the 2-HG concentration was calculated relative to water.RESULTS: When comparing the tumour data to control regions in both patients and healthy controls, we found that the choline/creatine and myo-inositol/creatine ratios were significantly increased and that the N-acetylaspartate/creatine and the neurotransmitter glutamate/creatine ratios were significantly decreased. The N-acetylaspartate/water and glutamate/water ratios were also significantly decreased. The lactate/water and lactate/creatine ratios showed increases, although not significant. The GABA/water ratio was significantly decreased, but the GABA/creatine ratio was not. MRS spectra showed the presence of 2-HG in three of the four patients studied. Three of the patients, including the MRS 2-HG-negative patient, were operated on, and all of them had the IDH mutation.CONCLUSION: Our findings were consistent with the existing literature on 3T and 7T MRS.
AB - BACKGROUND AND PURPOSE: Magnetic resonance spectroscopy (MRS)-a method of analysing metabolites in vivo-has been utilized in several studies of brain glioma biomarkers at lower field strengths. At ultra-high field strengths, MRS provides an improved signal-to-noise-ratio and spectral resolution, but 7T studies on patients with gliomas are sparse. The purpose of this exploratory study was to evaluate the potential clinical implication of the use of single-voxel MRS at 7T to assess metabolic information on lesions in a pilot cohort of patients with grade II and III gliomas.METHODS: We scanned seven patients and seven healthy controls using the semi-localization by adiabatic-selective refocusing sequence on a Philips Achieva 7T system with a standard dual-transmit head coil. The metabolic ratios were calculated relative to water and total creatine. Additionally, 2-hydroxyglutarate (2-HG) MRS was carried out in four of the patients, and the 2-HG concentration was calculated relative to water.RESULTS: When comparing the tumour data to control regions in both patients and healthy controls, we found that the choline/creatine and myo-inositol/creatine ratios were significantly increased and that the N-acetylaspartate/creatine and the neurotransmitter glutamate/creatine ratios were significantly decreased. The N-acetylaspartate/water and glutamate/water ratios were also significantly decreased. The lactate/water and lactate/creatine ratios showed increases, although not significant. The GABA/water ratio was significantly decreased, but the GABA/creatine ratio was not. MRS spectra showed the presence of 2-HG in three of the four patients studied. Three of the patients, including the MRS 2-HG-negative patient, were operated on, and all of them had the IDH mutation.CONCLUSION: Our findings were consistent with the existing literature on 3T and 7T MRS.
U2 - 10.3390/diagnostics13101805
DO - 10.3390/diagnostics13101805
M3 - Journal article
C2 - 37238288
VL - 13
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 10
M1 - 1805
ER -
ID: 363829938