Ribosomal stress-surveillance: three pathways is a magic number

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Ribosomal stress-surveillance : three pathways is a magic number. / Vind, Anna Constance; Genzor, Aitana Victoria; Bekker-Jensen, Simon.

I: Nucleic Acids Research, Bind 48, Nr. 19, 2020, s. 10648-10661.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Vind, AC, Genzor, AV & Bekker-Jensen, S 2020, 'Ribosomal stress-surveillance: three pathways is a magic number', Nucleic Acids Research, bind 48, nr. 19, s. 10648-10661. https://doi.org/10.1093/nar/gkaa757

APA

Vind, A. C., Genzor, A. V., & Bekker-Jensen, S. (2020). Ribosomal stress-surveillance: three pathways is a magic number. Nucleic Acids Research, 48(19), 10648-10661. https://doi.org/10.1093/nar/gkaa757

Vancouver

Vind AC, Genzor AV, Bekker-Jensen S. Ribosomal stress-surveillance: three pathways is a magic number. Nucleic Acids Research. 2020;48(19):10648-10661. https://doi.org/10.1093/nar/gkaa757

Author

Vind, Anna Constance ; Genzor, Aitana Victoria ; Bekker-Jensen, Simon. / Ribosomal stress-surveillance : three pathways is a magic number. I: Nucleic Acids Research. 2020 ; Bind 48, Nr. 19. s. 10648-10661.

Bibtex

@article{76c917465cdc47e591465de198ddaa75,
title = "Ribosomal stress-surveillance: three pathways is a magic number",
abstract = "Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative effects of harmful environmental stimuli. The stress- and mitogen-activated protein (MAP) kinases, p38 and JNK, are at the nexus of numerous stress responses, among these the ribotoxic stress response (RSR). Ribosomal impairment is detrimental to cell function as it disrupts protein synthesis, increase inflammatory signaling and, if unresolved, lead to cell death. In this review, we offer a general overview of the three main translation surveillance pathways; the RSR, Ribosome-associated Quality Control (RQC) and the Integrated Stress Response (ISR). We highlight recent advances made in defining activation mechanisms for these pathways and discuss their commonalities and differences. Finally, we reflect on the physiological role of the RSR and consider the therapeutic potential of targeting the sensing kinase ZAKα for treatment of ribotoxin exposure.",
author = "Vind, {Anna Constance} and Genzor, {Aitana Victoria} and Simon Bekker-Jensen",
year = "2020",
doi = "10.1093/nar/gkaa757",
language = "English",
volume = "48",
pages = "10648--10661",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "19",

}

RIS

TY - JOUR

T1 - Ribosomal stress-surveillance

T2 - three pathways is a magic number

AU - Vind, Anna Constance

AU - Genzor, Aitana Victoria

AU - Bekker-Jensen, Simon

PY - 2020

Y1 - 2020

N2 - Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative effects of harmful environmental stimuli. The stress- and mitogen-activated protein (MAP) kinases, p38 and JNK, are at the nexus of numerous stress responses, among these the ribotoxic stress response (RSR). Ribosomal impairment is detrimental to cell function as it disrupts protein synthesis, increase inflammatory signaling and, if unresolved, lead to cell death. In this review, we offer a general overview of the three main translation surveillance pathways; the RSR, Ribosome-associated Quality Control (RQC) and the Integrated Stress Response (ISR). We highlight recent advances made in defining activation mechanisms for these pathways and discuss their commonalities and differences. Finally, we reflect on the physiological role of the RSR and consider the therapeutic potential of targeting the sensing kinase ZAKα for treatment of ribotoxin exposure.

AB - Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative effects of harmful environmental stimuli. The stress- and mitogen-activated protein (MAP) kinases, p38 and JNK, are at the nexus of numerous stress responses, among these the ribotoxic stress response (RSR). Ribosomal impairment is detrimental to cell function as it disrupts protein synthesis, increase inflammatory signaling and, if unresolved, lead to cell death. In this review, we offer a general overview of the three main translation surveillance pathways; the RSR, Ribosome-associated Quality Control (RQC) and the Integrated Stress Response (ISR). We highlight recent advances made in defining activation mechanisms for these pathways and discuss their commonalities and differences. Finally, we reflect on the physiological role of the RSR and consider the therapeutic potential of targeting the sensing kinase ZAKα for treatment of ribotoxin exposure.

U2 - 10.1093/nar/gkaa757

DO - 10.1093/nar/gkaa757

M3 - Journal article

C2 - 32941609

AN - SCOPUS:85095799188

VL - 48

SP - 10648

EP - 10661

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 19

ER -

ID: 251585081