TY - JOUR

T1 - Protecting the Aging Genome

AU - Petr, Michael A.

AU - Tulika, Tulika

AU - Carmona-Marin, Lina M.

AU - Scheibye-Knudsen, Morten

PY - 2020

Y1 - 2020

N2 - Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage. Mutations in or failure of these pathways can lead to accelerated or premature aging and age-related decline in vital organs, supporting the hypothesis that maintaining a pristine genome is paramount for human health. Understanding how we cope with DNA damage could inform on the aging process and further on how deficient DNA maintenance manifests in age-related phenotypes. This knowledge may lead to the development of novel interventions promoting healthspan.

AB - Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage. Mutations in or failure of these pathways can lead to accelerated or premature aging and age-related decline in vital organs, supporting the hypothesis that maintaining a pristine genome is paramount for human health. Understanding how we cope with DNA damage could inform on the aging process and further on how deficient DNA maintenance manifests in age-related phenotypes. This knowledge may lead to the development of novel interventions promoting healthspan.

KW - aging

KW - aging interventions

KW - DNA damage

KW - DNA repair

KW - progeria

U2 - 10.1016/j.tcb.2019.12.001

DO - 10.1016/j.tcb.2019.12.001

M3 - Review

C2 - 31917080

AN - SCOPUS:85077376120

VL - 30

SP - 117

EP - 132

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

IS - 2

ER -