TY - JOUR

T1 - NAD+

T2 - A key metabolic regulator with great therapeutic potential

AU - Sultani, G.

AU - Samsudeen, A. F.

AU - Osborne, B.

AU - Turner, Nigel

N1 - Funding Information: Work in the laboratories of the authors is supported by fund- Publisher Copyright: © 2017 British Society for Neuroendocrinology

PY - 2017

Y1 - 2017

N2 - Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that serves an essential role in the catabolism of nutrients. Recently, there has been a surge of interest in NAD+ biology, with the recognition that NAD+ influences many biological processes beyond metabolism, including transcription, signalling and cell survival. There are a multitude of pathways involved in the synthesis and breakdown of NAD+, and alterations in NAD+ homeostasis have emerged as a common feature of a range of disease states. Here, we provide an overview of NAD+ metabolism and summarise progress on the development of NAD+-related therapeutics.

AB - Nicotinamide adenine dinucleotide (NAD+) is a ubiquitous metabolite that serves an essential role in the catabolism of nutrients. Recently, there has been a surge of interest in NAD+ biology, with the recognition that NAD+ influences many biological processes beyond metabolism, including transcription, signalling and cell survival. There are a multitude of pathways involved in the synthesis and breakdown of NAD+, and alterations in NAD+ homeostasis have emerged as a common feature of a range of disease states. Here, we provide an overview of NAD+ metabolism and summarise progress on the development of NAD+-related therapeutics.

KW - ageing

KW - metabolism

KW - NAD

KW - sirtuins

KW - therapeutic

U2 - 10.1111/jne.12508

DO - 10.1111/jne.12508

M3 - Review

C2 - 28718934

AN - SCOPUS:85032865048

VL - 29

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

IS - 10

M1 - e12508

ER -