Methylation and hydroxymethylation in cancer

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Standard

Methylation and hydroxymethylation in cancer. / Asmar, Fazila; Gillberg, Linn; Grønbæk, Kirsten.

Epigenetic Cancer Therapy [Second Edition]. 2. udg. Elsevier, 2023. s. 11-37.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Harvard

Asmar, F, Gillberg, L & Grønbæk, K 2023, Methylation and hydroxymethylation in cancer. i Epigenetic Cancer Therapy [Second Edition]. 2. udg, Elsevier, s. 11-37. https://doi.org/10.1016/B978-0-323-91367-6.00020-9

APA

Asmar, F., Gillberg, L., & Grønbæk, K. (2023). Methylation and hydroxymethylation in cancer. I Epigenetic Cancer Therapy [Second Edition] (2. udg., s. 11-37). Elsevier. https://doi.org/10.1016/B978-0-323-91367-6.00020-9

Vancouver

Asmar F, Gillberg L, Grønbæk K. Methylation and hydroxymethylation in cancer. I Epigenetic Cancer Therapy [Second Edition]. 2. udg. Elsevier. 2023. s. 11-37 https://doi.org/10.1016/B978-0-323-91367-6.00020-9

Author

Asmar, Fazila ; Gillberg, Linn ; Grønbæk, Kirsten. / Methylation and hydroxymethylation in cancer. Epigenetic Cancer Therapy [Second Edition]. 2. udg. Elsevier, 2023. s. 11-37

Bibtex

@inbook{683efd4adb974cb5825f37c1ed6b71a4,
title = "Methylation and hydroxymethylation in cancer",
abstract = "Genome-wide analyses have been used to characterize the genetic landscapes of many cancers. One of the most frequent classes of genes found to be mutated in cancer is the epigenetic regulators, providing a link between genetic alterations and epigenetic changes in cancer. In addition, multiple studies have reported aberrant DNA methylation and hydroxymethylation patterns as well as histone modifications in cancer. The recognition of the mutuality between genetic and epigenetic aberrations in cancer and the reversible features of epigenetic changes provide a rationale for combining epigenetic therapy with conventional chemotherapy and form basis for the development of novel and targeted treatment modalities. In this chapter, we review aberrant DNA methylation and hydroxymethylation patterns in cancer and mutations in epigenetic regulators involved in DNA methylation and hydroxymethylation and discuss the effect of these aberrations on tumorigenesis.",
keywords = "cancer, CpG islands, CpG shores, DNA demethylation, DNA hydroxymethylation, DNA methylation, DNA methyltransferases, Epigenetics, isocitrate dehydrogenases 1 and 2, regulatory elements, succinate dehydrogenases, TET family proteins",
author = "Fazila Asmar and Linn Gillberg and Kirsten Gr{\o}nb{\ae}k",
note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc. All rights reserved.",
year = "2023",
doi = "10.1016/B978-0-323-91367-6.00020-9",
language = "English",
pages = "11--37",
booktitle = "Epigenetic Cancer Therapy [Second Edition]",
publisher = "Elsevier",
edition = "2.",

}

RIS

TY - CHAP

T1 - Methylation and hydroxymethylation in cancer

AU - Asmar, Fazila

AU - Gillberg, Linn

AU - Grønbæk, Kirsten

N1 - Publisher Copyright: © 2023 Elsevier Inc. All rights reserved.

PY - 2023

Y1 - 2023

N2 - Genome-wide analyses have been used to characterize the genetic landscapes of many cancers. One of the most frequent classes of genes found to be mutated in cancer is the epigenetic regulators, providing a link between genetic alterations and epigenetic changes in cancer. In addition, multiple studies have reported aberrant DNA methylation and hydroxymethylation patterns as well as histone modifications in cancer. The recognition of the mutuality between genetic and epigenetic aberrations in cancer and the reversible features of epigenetic changes provide a rationale for combining epigenetic therapy with conventional chemotherapy and form basis for the development of novel and targeted treatment modalities. In this chapter, we review aberrant DNA methylation and hydroxymethylation patterns in cancer and mutations in epigenetic regulators involved in DNA methylation and hydroxymethylation and discuss the effect of these aberrations on tumorigenesis.

AB - Genome-wide analyses have been used to characterize the genetic landscapes of many cancers. One of the most frequent classes of genes found to be mutated in cancer is the epigenetic regulators, providing a link between genetic alterations and epigenetic changes in cancer. In addition, multiple studies have reported aberrant DNA methylation and hydroxymethylation patterns as well as histone modifications in cancer. The recognition of the mutuality between genetic and epigenetic aberrations in cancer and the reversible features of epigenetic changes provide a rationale for combining epigenetic therapy with conventional chemotherapy and form basis for the development of novel and targeted treatment modalities. In this chapter, we review aberrant DNA methylation and hydroxymethylation patterns in cancer and mutations in epigenetic regulators involved in DNA methylation and hydroxymethylation and discuss the effect of these aberrations on tumorigenesis.

KW - cancer

KW - CpG islands

KW - CpG shores

KW - DNA demethylation

KW - DNA hydroxymethylation

KW - DNA methylation

KW - DNA methyltransferases

KW - Epigenetics

KW - isocitrate dehydrogenases 1 and 2

KW - regulatory elements

KW - succinate dehydrogenases

KW - TET family proteins

UR - http://www.scopus.com/inward/record.url?scp=85160480433&partnerID=8YFLogxK

U2 - 10.1016/B978-0-323-91367-6.00020-9

DO - 10.1016/B978-0-323-91367-6.00020-9

M3 - Book chapter

AN - SCOPUS:85160480433

SP - 11

EP - 37

BT - Epigenetic Cancer Therapy [Second Edition]

PB - Elsevier

ER -

ID: 353803739