Evaluation of the effects of ezetimibe on albuminuria and kidney fat in individuals with type 2 diabetes and chronic kidney disease
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
To investigate the effects of ezetimibe on the urine albumin creatinine ratio (UACR) and kidney parenchyma fat content (kidney-PF) in individuals with type 2 diabetes (T2D) and early chronic kidney disease.
Materials and Methods
A randomized, double-blind, placebo-controlled study of ezetimibe 10 mg once daily for 16 weeks in individuals with T2D and a UACR of 30 mg/g or higher was conducted. Kidney-PF was assessed with magnetic resonance spectroscopy. Geometric mean changes from baseline were derived from linear regressions.
Results
A total of 49 participants were randomized to ezetimibe (n = 25) or placebo (n = 24). Overall, mean ± standard deviation age was 67 ± 7 years, body mass index was 31 ± 4 kg/m2 and the proportion of men was 84%. The mean estimated glomerular filtration rate was 76 ± 22 mL/min/1.73m2 and median (first-third quartile) UACR was 95 (41-297) mg/g. Median kidney-PF was 1.0% (0.3%-2.1%). Compared with placebo, ezetimibe did not significantly reduce UACR (mean [95% confidence interval] change: −3% [−28%-31%]) or kidney-PF (mean change: −38% [−66%-14%]). In participants with baseline kidney-PF above the median, ezetimibe reduced kidney-PF significantly (mean change: −60% [−84%-−3%]) compared with placebo, while the reduction in UACR was not significant (mean change: −28% [−54%-15%]).
Conclusions
Ezetimibe did not reduce the UACR or kidney-PF on top of modern T2D management. However, kidney-PF was reduced with ezetimibe in participants with high baseline kidney-PF.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Diabetes, Obesity and Metabolism |
| Vol/bind | 25 |
| Udgave nummer | 9 |
| Sider (fra-til) | 2605-2615 |
| Antal sider | 11 |
| ISSN | 1462-8902 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
We are sincerely grateful to all study participants for their time and dedication. We also wish to acknowledge the indispensable contributions made by laboratory technicians at SDCC (Dorthe Riis, Tina Ragnholm Juhl, Jessie Armand Hermann, Maja Lis Dybdahl Halkjær, Annette Vinding, Eva Littrup Andersen and Helle Reinikka Christensen) who handled all biochemistry sampling and analyses, the study nurse Jeanne Maibom, who provided practical assistance, and the technical university students who conducted the numerous MRI scans and also contributed to the processing of the MRI/MRS data (Tanne Stephanie Wiberg Larsson, Gidega Vijayakumar, Büsra Köylü, Mathilde Overgaard Lauersen and Linnéa Haugen). This study was funded by internal funds mostly with a contribution from the PROTON project grant from the Novo Nordisk Foundation (grant number: NNF14OC0013659).
Funding Information:
We are sincerely grateful to all study participants for their time and dedication. We also wish to acknowledge the indispensable contributions made by laboratory technicians at SDCC (Dorthe Riis, Tina Ragnholm Juhl, Jessie Armand Hermann, Maja Lis Dybdahl Halkjær, Annette Vinding, Eva Littrup Andersen and Helle Reinikka Christensen) who handled all biochemistry sampling and analyses, the study nurse Jeanne Maibom, who provided practical assistance, and the technical university students who conducted the numerous MRI scans and also contributed to the processing of the MRI/MRS data (Tanne Stephanie Wiberg Larsson, Gidega Vijayakumar, Büsra Köylü, Mathilde Overgaard Lauersen and Linnéa Haugen). This study was funded by internal funds mostly with a contribution from the PROTON project grant from the Novo Nordisk Foundation (grant number: NNF14OC0013659).
Publisher Copyright:
© 2023 John Wiley & Sons Ltd.
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