Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease

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Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease. / Ronn, Tina; Perfilyev, Alexander; Jonsson, Josefine; Eriksson, Karl-Fredrik; Jorgensen, Sine W.; Brons, Charlotte; Gillberg, Linn; Vaag, Allan; Stener-Victorin, Elisabet; Ling, Charlotte.

I: Human Molecular Genetics, Bind 32, Nr. 11, 2023, s. 1875–1887.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ronn, T, Perfilyev, A, Jonsson, J, Eriksson, K-F, Jorgensen, SW, Brons, C, Gillberg, L, Vaag, A, Stener-Victorin, E & Ling, C 2023, 'Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease', Human Molecular Genetics, bind 32, nr. 11, s. 1875–1887. https://doi.org/10.1093/hmg/ddad024

APA

Ronn, T., Perfilyev, A., Jonsson, J., Eriksson, K-F., Jorgensen, S. W., Brons, C., Gillberg, L., Vaag, A., Stener-Victorin, E., & Ling, C. (2023). Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease. Human Molecular Genetics, 32(11), 1875–1887. https://doi.org/10.1093/hmg/ddad024

Vancouver

Ronn T, Perfilyev A, Jonsson J, Eriksson K-F, Jorgensen SW, Brons C o.a. Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease. Human Molecular Genetics. 2023;32(11):1875–1887. https://doi.org/10.1093/hmg/ddad024

Author

Ronn, Tina ; Perfilyev, Alexander ; Jonsson, Josefine ; Eriksson, Karl-Fredrik ; Jorgensen, Sine W. ; Brons, Charlotte ; Gillberg, Linn ; Vaag, Allan ; Stener-Victorin, Elisabet ; Ling, Charlotte. / Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease. I: Human Molecular Genetics. 2023 ; Bind 32, Nr. 11. s. 1875–1887.

Bibtex

@article{cbc2c570de224dbdbd6845bc8197fe7d,
title = "Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease",
abstract = "Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. DNA methylation and gene expression were analysed genome-wide in subcutaneous adipose tissue from two different cohorts, including 85 men and 93 women, respectively. Associations between DNA methylation and circulating levels of triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol were analysed. Causal mediation analyses tested if adipose tissue DNA methylation mediates the effects of triglycerides on gene expression or insulin resistance. We found 115 novel associations between triglycerides and adipose tissue DNA methylation, e.g. in the promoter of RFS1, ARID2 and HOXA5 in the male cohort (P",
keywords = "EPIGENETIC CHANGES, BIOMARKERS, DISCOVERY, PROTEIN, ISLETS, AGE",
author = "Tina Ronn and Alexander Perfilyev and Josefine Jonsson and Karl-Fredrik Eriksson and Jorgensen, {Sine W.} and Charlotte Brons and Linn Gillberg and Allan Vaag and Elisabet Stener-Victorin and Charlotte Ling",
year = "2023",
doi = "10.1093/hmg/ddad024",
language = "English",
volume = "32",
pages = "1875–1887",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease

AU - Ronn, Tina

AU - Perfilyev, Alexander

AU - Jonsson, Josefine

AU - Eriksson, Karl-Fredrik

AU - Jorgensen, Sine W.

AU - Brons, Charlotte

AU - Gillberg, Linn

AU - Vaag, Allan

AU - Stener-Victorin, Elisabet

AU - Ling, Charlotte

PY - 2023

Y1 - 2023

N2 - Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. DNA methylation and gene expression were analysed genome-wide in subcutaneous adipose tissue from two different cohorts, including 85 men and 93 women, respectively. Associations between DNA methylation and circulating levels of triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol were analysed. Causal mediation analyses tested if adipose tissue DNA methylation mediates the effects of triglycerides on gene expression or insulin resistance. We found 115 novel associations between triglycerides and adipose tissue DNA methylation, e.g. in the promoter of RFS1, ARID2 and HOXA5 in the male cohort (P

AB - Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. Hence, our aim was to investigate the association between circulating lipids and DNA methylation levels in human adipose tissue. DNA methylation and gene expression were analysed genome-wide in subcutaneous adipose tissue from two different cohorts, including 85 men and 93 women, respectively. Associations between DNA methylation and circulating levels of triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol were analysed. Causal mediation analyses tested if adipose tissue DNA methylation mediates the effects of triglycerides on gene expression or insulin resistance. We found 115 novel associations between triglycerides and adipose tissue DNA methylation, e.g. in the promoter of RFS1, ARID2 and HOXA5 in the male cohort (P

KW - EPIGENETIC CHANGES

KW - BIOMARKERS

KW - DISCOVERY

KW - PROTEIN

KW - ISLETS

KW - AGE

U2 - 10.1093/hmg/ddad024

DO - 10.1093/hmg/ddad024

M3 - Journal article

C2 - 36752523

VL - 32

SP - 1875

EP - 1887

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 11

ER -

ID: 340532935