CD38 regulates ovarian function and fecundity via NAD+ metabolism

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

CD38 regulates ovarian function and fecundity via NAD+ metabolism. / Perrone, Rosalba; Ashok Kumaar, Prasanna Vadhana; Haky, Lauren; Hahn, Cosmo; Riley, Rebeccah; Balough, Julia; Zaza, Giuliana; Soygur, Bikem; Hung, Kaitlyn; Prado, Leandro; Kasler, Herbert G.; Tiwari, Ritesh; Matsui, Hiroyuki; Hormazabal, Genesis Vega; Heckenbach, Indra; Scheibye-Knudsen, Morten; Duncan, Francesca E.; Verdin, Eric.

I: iScience, Bind 26, Nr. 10, 107949, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Perrone, R, Ashok Kumaar, PV, Haky, L, Hahn, C, Riley, R, Balough, J, Zaza, G, Soygur, B, Hung, K, Prado, L, Kasler, HG, Tiwari, R, Matsui, H, Hormazabal, GV, Heckenbach, I, Scheibye-Knudsen, M, Duncan, FE & Verdin, E 2023, 'CD38 regulates ovarian function and fecundity via NAD+ metabolism', iScience, bind 26, nr. 10, 107949. https://doi.org/10.1016/j.isci.2023.107949

APA

Perrone, R., Ashok Kumaar, P. V., Haky, L., Hahn, C., Riley, R., Balough, J., Zaza, G., Soygur, B., Hung, K., Prado, L., Kasler, H. G., Tiwari, R., Matsui, H., Hormazabal, G. V., Heckenbach, I., Scheibye-Knudsen, M., Duncan, F. E., & Verdin, E. (2023). CD38 regulates ovarian function and fecundity via NAD+ metabolism. iScience, 26(10), [107949]. https://doi.org/10.1016/j.isci.2023.107949

Vancouver

Perrone R, Ashok Kumaar PV, Haky L, Hahn C, Riley R, Balough J o.a. CD38 regulates ovarian function and fecundity via NAD+ metabolism. iScience. 2023;26(10). 107949. https://doi.org/10.1016/j.isci.2023.107949

Author

Perrone, Rosalba ; Ashok Kumaar, Prasanna Vadhana ; Haky, Lauren ; Hahn, Cosmo ; Riley, Rebeccah ; Balough, Julia ; Zaza, Giuliana ; Soygur, Bikem ; Hung, Kaitlyn ; Prado, Leandro ; Kasler, Herbert G. ; Tiwari, Ritesh ; Matsui, Hiroyuki ; Hormazabal, Genesis Vega ; Heckenbach, Indra ; Scheibye-Knudsen, Morten ; Duncan, Francesca E. ; Verdin, Eric. / CD38 regulates ovarian function and fecundity via NAD+ metabolism. I: iScience. 2023 ; Bind 26, Nr. 10.

Bibtex

@article{3f82d96ac25f420a96b6a429f828d404,
title = "CD38 regulates ovarian function and fecundity via NAD+ metabolism",
abstract = "Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that CD38, an NAD+ consuming enzyme, is expressed in the ovarian extrafollicular space, primarily in immune cells, and its levels increase with reproductive age. Reproductively young mice lacking CD38 exhibit larger primordial follicle pools, elevated ovarian NAD+ levels, and increased fecundity relative to wild type controls. This larger ovarian reserve results from a prolonged window of follicle formation during early development. However, the beneficial effect of CD38 loss on reproductive function is not maintained at advanced age. Our results demonstrate a novel role of CD38 in regulating ovarian NAD+ metabolism and establishing the ovarian reserve, a critical process that dictates a female's reproductive lifespan.",
keywords = "Biochemistry, Biological sciences, Physiology",
author = "Rosalba Perrone and {Ashok Kumaar}, {Prasanna Vadhana} and Lauren Haky and Cosmo Hahn and Rebeccah Riley and Julia Balough and Giuliana Zaza and Bikem Soygur and Kaitlyn Hung and Leandro Prado and Kasler, {Herbert G.} and Ritesh Tiwari and Hiroyuki Matsui and Hormazabal, {Genesis Vega} and Indra Heckenbach and Morten Scheibye-Knudsen and Duncan, {Francesca E.} and Eric Verdin",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.isci.2023.107949",
language = "English",
volume = "26",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - CD38 regulates ovarian function and fecundity via NAD+ metabolism

AU - Perrone, Rosalba

AU - Ashok Kumaar, Prasanna Vadhana

AU - Haky, Lauren

AU - Hahn, Cosmo

AU - Riley, Rebeccah

AU - Balough, Julia

AU - Zaza, Giuliana

AU - Soygur, Bikem

AU - Hung, Kaitlyn

AU - Prado, Leandro

AU - Kasler, Herbert G.

AU - Tiwari, Ritesh

AU - Matsui, Hiroyuki

AU - Hormazabal, Genesis Vega

AU - Heckenbach, Indra

AU - Scheibye-Knudsen, Morten

AU - Duncan, Francesca E.

AU - Verdin, Eric

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that CD38, an NAD+ consuming enzyme, is expressed in the ovarian extrafollicular space, primarily in immune cells, and its levels increase with reproductive age. Reproductively young mice lacking CD38 exhibit larger primordial follicle pools, elevated ovarian NAD+ levels, and increased fecundity relative to wild type controls. This larger ovarian reserve results from a prolonged window of follicle formation during early development. However, the beneficial effect of CD38 loss on reproductive function is not maintained at advanced age. Our results demonstrate a novel role of CD38 in regulating ovarian NAD+ metabolism and establishing the ovarian reserve, a critical process that dictates a female's reproductive lifespan.

AB - Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that CD38, an NAD+ consuming enzyme, is expressed in the ovarian extrafollicular space, primarily in immune cells, and its levels increase with reproductive age. Reproductively young mice lacking CD38 exhibit larger primordial follicle pools, elevated ovarian NAD+ levels, and increased fecundity relative to wild type controls. This larger ovarian reserve results from a prolonged window of follicle formation during early development. However, the beneficial effect of CD38 loss on reproductive function is not maintained at advanced age. Our results demonstrate a novel role of CD38 in regulating ovarian NAD+ metabolism and establishing the ovarian reserve, a critical process that dictates a female's reproductive lifespan.

KW - Biochemistry

KW - Biological sciences

KW - Physiology

U2 - 10.1016/j.isci.2023.107949

DO - 10.1016/j.isci.2023.107949

M3 - Journal article

C2 - 37822499

AN - SCOPUS:85172884910

VL - 26

JO - iScience

JF - iScience

SN - 2589-0042

IS - 10

M1 - 107949

ER -

ID: 371276147