An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway: a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5'-diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7 dysregulation in the epidermis. This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration. Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Science |
Vol/bind | 341 |
Udgave nummer | 6152 |
Sider (fra-til) | 1404-8 |
Antal sider | 5 |
ISSN | 0036-8075 |
DOI | |
Status | Udgivet - 20 sep. 2013 |
ID: 50947454