Age estimation from sleep studies using deep learning predicts life expectancy
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Sleep disturbances increase with age and are predictors of mortality. Here, we present deep neural networks that estimate age and mortality risk through polysomnograms (PSGs). Aging was modeled using 2500 PSGs and tested in 10,699 PSGs from men and women in seven different cohorts aged between 20 and 90. Ages were estimated with a mean absolute error of 5.8 ± 1.6 years, while basic sleep scoring measures had an error of 14.9 ± 6.29 years. After controlling for demographics, sleep, and health covariates, each 10-year increment in age estimate error (AEE) was associated with increased all-cause mortality rate of 29% (95% confidence interval: 20–39%). An increase from −10 to +10 years in AEE translates to an estimated decreased life expectancy of 8.7 years (95% confidence interval: 6.1–11.4 years). Greater AEE was mostly reflected in increased sleep fragmentation, suggesting this is an important biomarker of future health independent of sleep apnea.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 103 |
| Tidsskrift | npj Digital Medicine |
| Vol/bind | 5 |
| Udgave nummer | 1 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This research was supported by the Danish Center for Sleep Medicine, the Technical University of Denmark, and the Klarman Family Foundation. Additional support to A.B.-K. was provided by the Stibo, Oberstløjtnant Max Nørgaard & Hustru Magda Nørgaards, Otto Mønsted, Augustinus, Knud Højgaard, William Demant, Vera & Carl Johan Michaelsens, Tranes, Marie & M.B. Richters Fond, and IDAs & Berg-Nielsens foundations. The Stanford Technology, Analytics and Genomics in Sleep (STAGES) study was funded by the Klarman Family Foundation. The Sleep Heart Health Study (SHHS) was supported by National Heart, Lung, and Blood Institute cooperative agreements U01HL53916 (University of California, Davis), U01HL53931 (New York University), U01HL53934 (University of Minnesota), U01HL53937 and U01HL64360 (Johns Hopkins University), U01HL53938 (University of Arizona), U01HL53940 (University of Washington), U01HL53941 (Boston University), and U01HL63463 (Case Western Reserve University). The Cleveland Family Study (CFS) was supported by grants from the National Institutes of Health (HL46380, M01 RR00080-39, T32-HL07567, RO1-46380). The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128. The National Heart, Lung, and Blood Institute (NHLBI) provides funding for the MrOS Sleep ancillary study “Outcomes of Sleep Disorders in Older Men” under the following grant numbers: R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, and R01 HL070839. See MrOs online public data release website: https://mrosonline.ucsf.edu. The Home Positive Airway Pressure study (HomePAP) was supported by the American Sleep Medicine Foundation 38-PM-07 Grant: Portable Monitoring for the Diagnosis and Management of OSA. This Wisconsin Sleep Cohort Study was supported by the U.S. National Institutes of Health, National Heart, Lung, and Blood Institute (R01HL62252), National Institute on Aging (R01AG036838, R01AG058680), and the National Center for Research Resources (1UL1RR025011). The National Sleep Research Resource was supported by the U.S. National Institutes of Health, National Heart Lung and Blood Institute (R24 HL114473, 75N92019R002).
Funding Information:
This research was supported by the Danish Center for Sleep Medicine, the Technical University of Denmark, and the Klarman Family Foundation. Additional support to A.B.-K. was provided by the Stibo, Oberstløjtnant Max Nørgaard & Hustru Magda Nørgaards, Otto Mønsted, Augustinus, Knud Højgaard, William Demant, Vera & Carl Johan Michaelsens, Tranes, Marie & M.B. Richters Fond, and IDAs & Berg-Nielsens foundations. The Stanford Technology, Analytics and Genomics in Sleep (STAGES) study was funded by the Klarman Family Foundation. The Sleep Heart Health Study (SHHS) was supported by National Heart, Lung, and Blood Institute cooperative agreements U01HL53916 (University of California, Davis), U01HL53931 (New York University), U01HL53934 (University of Minnesota), U01HL53937 and U01HL64360 (Johns Hopkins University), U01HL53938 (University of Arizona), U01HL53940 (University of Washington), U01HL53941 (Boston University), and U01HL63463 (Case Western Reserve University). The Cleveland Family Study (CFS) was supported by grants from the National Institutes of Health (HL46380, M01 RR00080-39, T32-HL07567, RO1-46380). The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128. The National Heart, Lung, and Blood Institute (NHLBI) provides funding for the MrOS Sleep ancillary study “Outcomes of Sleep Disorders in Older Men” under the following grant numbers: R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, and R01 HL070839. See MrOs online public data release website: https://mrosonline.ucsf.edu . The Home Positive Airway Pressure study (HomePAP) was supported by the American Sleep Medicine Foundation 38-PM-07 Grant: Portable Monitoring for the Diagnosis and Management of OSA. This Wisconsin Sleep Cohort Study was supported by the U.S. National Institutes of Health, National Heart, Lung, and Blood Institute (R01HL62252), National Institute on Aging (R01AG036838, R01AG058680), and the National Center for Research Resources (1UL1RR025011). The National Sleep Research Resource was supported by the U.S. National Institutes of Health, National Heart Lung and Blood Institute (R24 HL114473, 75N92019R002).
Publisher Copyright:
© 2022, The Author(s).
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