Acetylation regulates WRN catalytic activities and affects base excision DNA repair
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltransferases is of key interest because of its potential importance in aging, DNA repair and transcription.
Originalsprog | Engelsk |
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Tidsskrift | P L o S One |
Vol/bind | 3 |
Udgave nummer | 4 |
Sider (fra-til) | e1918 |
ISSN | 1932-6203 |
DOI | |
Status | Udgivet - jan. 2008 |
ID: 32949176