Periodontal Inflammation in Relation to Cognitive Function in an Older Adult Danish Population
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Periodontal Inflammation in Relation to Cognitive Function in an Older Adult Danish Population. / Kamer, Angela R.; Morse, Douglas E.; Holm-Pedersen, Poul; Mortensen, Erik L.; Avlund, Kirsten.
Handbook of Microbiome and Gut-Brain-Axis in Alzheimer�s Disease. ed. / Giulio Maria Pasinetti. IOS Press BV, 2022. p. 581-592 (Advances in Alzheimer's Disease, Vol. 9).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Periodontal Inflammation in Relation to Cognitive Function in an Older Adult Danish Population
AU - Kamer, Angela R.
AU - Morse, Douglas E.
AU - Holm-Pedersen, Poul
AU - Mortensen, Erik L.
AU - Avlund, Kirsten
N1 - Publisher Copyright: © 2022 The authors and IOS Press. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Inflammation plays a significant role in Alzheimer's disease (AD) pathogenesis. Studies have shown that systemic, peripheral infections affect AD patients. Cognitive dysfunction is a consistent finding in AD and periodontal disease is a chronic, peripheral infection often resulting in tooth loss. We hypothesized that older adults with periodontal inflammation (PI) or many missing teeth would show impaired cognition compared to subjects without PI or with few missing teeth, and among subjects with PI, those with many missing teeth would show impaired cognition compared to those with few missing teeth. The effect of PI/tooth loss on cognitive function [measured by Digit Symbol (DST) and Block Design (BDT) tests] was assessed in 70-year old Danish subjects. We found: 1) subjects with PI obtained lower mean DST scores compared to subjects without PI (p < 0.05); 2) subjects with many missing teeth had lower mean DST and BDT scores compared to subjects with few missing teeth (p < 0.05); 3) the association of PI with DST and BDT scores was dependant on the number of missing teeth (interaction: p = 0.03 and p = 0.06); and 4) education and previous cognitive scores (age 50) were important covariates. Subjects with PI had significantly lower adjusted mean DST scores compared to subjects without PI. However for adjusted BDT, the significance held only for subjects with few missing teeth. No difference in the adjusted DST and BDT scores was seen between subjects with many missing teeth compared to those with few missing teeth. These results support the hypothesis that PI may affect cognition.
AB - Inflammation plays a significant role in Alzheimer's disease (AD) pathogenesis. Studies have shown that systemic, peripheral infections affect AD patients. Cognitive dysfunction is a consistent finding in AD and periodontal disease is a chronic, peripheral infection often resulting in tooth loss. We hypothesized that older adults with periodontal inflammation (PI) or many missing teeth would show impaired cognition compared to subjects without PI or with few missing teeth, and among subjects with PI, those with many missing teeth would show impaired cognition compared to those with few missing teeth. The effect of PI/tooth loss on cognitive function [measured by Digit Symbol (DST) and Block Design (BDT) tests] was assessed in 70-year old Danish subjects. We found: 1) subjects with PI obtained lower mean DST scores compared to subjects without PI (p < 0.05); 2) subjects with many missing teeth had lower mean DST and BDT scores compared to subjects with few missing teeth (p < 0.05); 3) the association of PI with DST and BDT scores was dependant on the number of missing teeth (interaction: p = 0.03 and p = 0.06); and 4) education and previous cognitive scores (age 50) were important covariates. Subjects with PI had significantly lower adjusted mean DST scores compared to subjects without PI. However for adjusted BDT, the significance held only for subjects with few missing teeth. No difference in the adjusted DST and BDT scores was seen between subjects with many missing teeth compared to those with few missing teeth. These results support the hypothesis that PI may affect cognition.
KW - Alzheimer's disease
KW - BDT
KW - cognition
KW - DST
KW - inflammation
KW - periodontal disease
KW - tooth loss
U2 - 10.3233/AIAD220037
DO - 10.3233/AIAD220037
M3 - Book chapter
AN - SCOPUS:85134271930
T3 - Advances in Alzheimer's Disease
SP - 581
EP - 592
BT - Handbook of Microbiome and Gut-Brain-Axis in Alzheimer�s Disease
A2 - Pasinetti, Giulio Maria
PB - IOS Press BV
ER -
ID: 321464406