Standard
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. / Lee, Patty J.; Benz, Christopher C.; Blood, Philip; Börner, Katy; Campisi, Judith; Chen, Feng; Daldrup-Link, Heike; De Jager, Phil; Ding, Li; Duncan, Francesca E.; Eickelberg, Oliver; Fan, Rong; Finkel, Toren; Furman, David; Garovic, Vesna; Gehlenborg, Nils; Glass, Carolyn; Heckenbach, Indra; Joseph, Ziv Bar; Katiyar, Pragati; Kim, So Jin; Königshoff, Melanie; Kuchel, George A.; Lee, Haesung; Lee, Jun Hee; Ma, Jian; Ma, Qin; Melov, Simon; Metis, Kay; Mora, Ana L.; Musi, Nicolas; Neretti, Nicola; Passos, João F.; Rahman, Irfan; Rivera-Mulia, Juan Carlos; Robson, Paul; Rojas, Mauricio; Roy, Ananda L.; Scheibye-Knudsen, Morten; Schilling, Birgit; Shi, Pixu; Silverstein, Jonathan C.; Suryadevara, Vidyani; Xie, Jichun; Wang, Jinhua; Wong, A. Ian; Niedernhofer, Laura J.; Wang, Siyuan; Anvari, Hannah; Balough, Julia; Stanford TDA; University of Connecticut TMC; University of Michigan TDA; University of Minnesota TMC; University of Pittsburgh TMC; University of Washington TDA; Washington University TMC; Yale TMC; SenNet Consortium; Writing Group; Brown University TDA; Buck Institute for Research on Aging TMC/TDA; Consortium Organization and Data Coordinating Center (CODCC); Columbia TMC; Duke University TMC; Massachusetts General Hospital TDA; Mayo Clinic TDA; National Institute of Health (NIH).
In:
Nature Aging, Vol. 2, No. 12, 2022, p. 1090-1100.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Lee, PJ, Benz, CC, Blood, P, Börner, K, Campisi, J, Chen, F, Daldrup-Link, H, De Jager, P, Ding, L, Duncan, FE, Eickelberg, O, Fan, R, Finkel, T, Furman, D, Garovic, V, Gehlenborg, N, Glass, C
, Heckenbach, I, Joseph, ZB, Katiyar, P, Kim, SJ, Königshoff, M, Kuchel, GA, Lee, H, Lee, JH, Ma, J, Ma, Q, Melov, S, Metis, K, Mora, AL, Musi, N, Neretti, N, Passos, JF, Rahman, I, Rivera-Mulia, JC, Robson, P, Rojas, M, Roy, AL
, Scheibye-Knudsen, M, Schilling, B, Shi, P, Silverstein, JC, Suryadevara, V, Xie, J, Wang, J, Wong, AI, Niedernhofer, LJ, Wang, S, Anvari, H, Balough, J, Stanford TDA, University of Connecticut TMC, University of Michigan TDA, University of Minnesota TMC, University of Pittsburgh TMC, University of Washington TDA, Washington University TMC, Yale TMC, SenNet Consortium, Writing Group, Brown University TDA, Buck Institute for Research on Aging TMC/TDA, Consortium Organization and Data Coordinating Center (CODCC), Columbia TMC, Duke University TMC, Massachusetts General Hospital TDA, Mayo Clinic TDA & National Institute of Health (NIH) 2022, '
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health',
Nature Aging, vol. 2, no. 12, pp. 1090-1100.
https://doi.org/10.1038/s43587-022-00326-5
APA
Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., Ding, L., Duncan, F. E., Eickelberg, O., Fan, R., Finkel, T., Furman, D., Garovic, V., Gehlenborg, N., Glass, C.
, Heckenbach, I., Joseph, Z. B., ... National Institute of Health (NIH) (2022).
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.
Nature Aging,
2(12), 1090-1100.
https://doi.org/10.1038/s43587-022-00326-5
Vancouver
Lee PJ, Benz CC, Blood P, Börner K, Campisi J, Chen F et al.
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.
Nature Aging. 2022;2(12):1090-1100.
https://doi.org/10.1038/s43587-022-00326-5
Author
Lee, Patty J. ; Benz, Christopher C. ; Blood, Philip ; Börner, Katy ; Campisi, Judith ; Chen, Feng ; Daldrup-Link, Heike ; De Jager, Phil ; Ding, Li ; Duncan, Francesca E. ; Eickelberg, Oliver ; Fan, Rong ; Finkel, Toren ; Furman, David ; Garovic, Vesna ; Gehlenborg, Nils ; Glass, Carolyn ; Heckenbach, Indra ; Joseph, Ziv Bar ; Katiyar, Pragati ; Kim, So Jin ; Königshoff, Melanie ; Kuchel, George A. ; Lee, Haesung ; Lee, Jun Hee ; Ma, Jian ; Ma, Qin ; Melov, Simon ; Metis, Kay ; Mora, Ana L. ; Musi, Nicolas ; Neretti, Nicola ; Passos, João F. ; Rahman, Irfan ; Rivera-Mulia, Juan Carlos ; Robson, Paul ; Rojas, Mauricio ; Roy, Ananda L. ; Scheibye-Knudsen, Morten ; Schilling, Birgit ; Shi, Pixu ; Silverstein, Jonathan C. ; Suryadevara, Vidyani ; Xie, Jichun ; Wang, Jinhua ; Wong, A. Ian ; Niedernhofer, Laura J. ; Wang, Siyuan ; Anvari, Hannah ; Balough, Julia ; Stanford TDA ; University of Connecticut TMC ; University of Michigan TDA ; University of Minnesota TMC ; University of Pittsburgh TMC ; University of Washington TDA ; Washington University TMC ; Yale TMC ; SenNet Consortium ; Writing Group ; Brown University TDA ; Buck Institute for Research on Aging TMC/TDA ; Consortium Organization and Data Coordinating Center (CODCC) ; Columbia TMC ; Duke University TMC ; Massachusetts General Hospital TDA ; Mayo Clinic TDA ; National Institute of Health (NIH). / NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. In: Nature Aging. 2022 ; Vol. 2, No. 12. pp. 1090-1100.
Bibtex
@article{8d717e9c1e724be5956cbe8036dcc49b,
title = "NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health",
abstract = "Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and their detection a priority. The Cellular Senescence Network (SenNet), a National Institutes of Health Common Fund initiative, was established to address this need. The goal of SenNet is to map SnCs across the human lifespan to advance diagnostic and therapeutic approaches to improve human health. State-of-the-art methods will be applied to identify, define and map SnCs in 18 human tissues. A common coordinate framework will integrate data to create four-dimensional SnC atlases. Other key SenNet deliverables include innovative tools and technologies to detect SnCs, new SnC biomarkers and extensive public multi-omics datasets. This Perspective lays out the impetus, goals, approaches and products of SenNet.",
author = "Lee, {Patty J.} and Benz, {Christopher C.} and Philip Blood and Katy B{\"o}rner and Judith Campisi and Feng Chen and Heike Daldrup-Link and {De Jager}, Phil and Li Ding and Duncan, {Francesca E.} and Oliver Eickelberg and Rong Fan and Toren Finkel and David Furman and Vesna Garovic and Nils Gehlenborg and Carolyn Glass and Indra Heckenbach and Joseph, {Ziv Bar} and Pragati Katiyar and Kim, {So Jin} and Melanie K{\"o}nigshoff and Kuchel, {George A.} and Haesung Lee and Lee, {Jun Hee} and Jian Ma and Qin Ma and Simon Melov and Kay Metis and Mora, {Ana L.} and Nicolas Musi and Nicola Neretti and Passos, {Jo{\~a}o F.} and Irfan Rahman and Rivera-Mulia, {Juan Carlos} and Paul Robson and Mauricio Rojas and Roy, {Ananda L.} and Morten Scheibye-Knudsen and Birgit Schilling and Pixu Shi and Silverstein, {Jonathan C.} and Vidyani Suryadevara and Jichun Xie and Jinhua Wang and Wong, {A. Ian} and Niedernhofer, {Laura J.} and Siyuan Wang and Hannah Anvari and Julia Balough and {Stanford TDA} and {University of Connecticut TMC} and {University of Michigan TDA} and {University of Minnesota TMC} and {University of Pittsburgh TMC} and {University of Washington TDA} and {Washington University TMC} and {Yale TMC} and {SenNet Consortium} and {Writing Group} and {Brown University TDA} and {Buck Institute for Research on Aging TMC/TDA} and {Consortium Organization and Data Coordinating Center (CODCC)} and {Columbia TMC} and {Duke University TMC} and {Massachusetts General Hospital TDA} and {Mayo Clinic TDA} and {National Institute of Health (NIH)}",
note = "Publisher Copyright: {\textcopyright} 2022, Springer Nature America, Inc.",
year = "2022",
doi = "10.1038/s43587-022-00326-5",
language = "English",
volume = "2",
pages = "1090--1100",
journal = "Nature Aging",
issn = "2662-8465",
publisher = "Nature Research",
number = "12",
}
RIS
TY - JOUR
T1 - NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
AU - Lee, Patty J.
AU - Benz, Christopher C.
AU - Blood, Philip
AU - Börner, Katy
AU - Campisi, Judith
AU - Chen, Feng
AU - Daldrup-Link, Heike
AU - De Jager, Phil
AU - Ding, Li
AU - Duncan, Francesca E.
AU - Eickelberg, Oliver
AU - Fan, Rong
AU - Finkel, Toren
AU - Furman, David
AU - Garovic, Vesna
AU - Gehlenborg, Nils
AU - Glass, Carolyn
AU - Heckenbach, Indra
AU - Joseph, Ziv Bar
AU - Katiyar, Pragati
AU - Kim, So Jin
AU - Königshoff, Melanie
AU - Kuchel, George A.
AU - Lee, Haesung
AU - Lee, Jun Hee
AU - Ma, Jian
AU - Ma, Qin
AU - Melov, Simon
AU - Metis, Kay
AU - Mora, Ana L.
AU - Musi, Nicolas
AU - Neretti, Nicola
AU - Passos, João F.
AU - Rahman, Irfan
AU - Rivera-Mulia, Juan Carlos
AU - Robson, Paul
AU - Rojas, Mauricio
AU - Roy, Ananda L.
AU - Scheibye-Knudsen, Morten
AU - Schilling, Birgit
AU - Shi, Pixu
AU - Silverstein, Jonathan C.
AU - Suryadevara, Vidyani
AU - Xie, Jichun
AU - Wang, Jinhua
AU - Wong, A. Ian
AU - Niedernhofer, Laura J.
AU - Wang, Siyuan
AU - Anvari, Hannah
AU - Balough, Julia
AU - Stanford TDA
AU - University of Connecticut TMC
AU - University of Michigan TDA
AU - University of Minnesota TMC
AU - University of Pittsburgh TMC
AU - University of Washington TDA
AU - Washington University TMC
AU - Yale TMC
AU - SenNet Consortium
AU - Writing Group
AU - Brown University TDA
AU - Buck Institute for Research on Aging TMC/TDA
AU - Consortium Organization and Data Coordinating Center (CODCC)
AU - Columbia TMC
AU - Duke University TMC
AU - Massachusetts General Hospital TDA
AU - Mayo Clinic TDA
AU - National Institute of Health (NIH)
N1 - Publisher Copyright:
© 2022, Springer Nature America, Inc.
PY - 2022
Y1 - 2022
N2 - Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and their detection a priority. The Cellular Senescence Network (SenNet), a National Institutes of Health Common Fund initiative, was established to address this need. The goal of SenNet is to map SnCs across the human lifespan to advance diagnostic and therapeutic approaches to improve human health. State-of-the-art methods will be applied to identify, define and map SnCs in 18 human tissues. A common coordinate framework will integrate data to create four-dimensional SnC atlases. Other key SenNet deliverables include innovative tools and technologies to detect SnCs, new SnC biomarkers and extensive public multi-omics datasets. This Perspective lays out the impetus, goals, approaches and products of SenNet.
AB - Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and their detection a priority. The Cellular Senescence Network (SenNet), a National Institutes of Health Common Fund initiative, was established to address this need. The goal of SenNet is to map SnCs across the human lifespan to advance diagnostic and therapeutic approaches to improve human health. State-of-the-art methods will be applied to identify, define and map SnCs in 18 human tissues. A common coordinate framework will integrate data to create four-dimensional SnC atlases. Other key SenNet deliverables include innovative tools and technologies to detect SnCs, new SnC biomarkers and extensive public multi-omics datasets. This Perspective lays out the impetus, goals, approaches and products of SenNet.
U2 - 10.1038/s43587-022-00326-5
DO - 10.1038/s43587-022-00326-5
M3 - Journal article
C2 - 36936385
AN - SCOPUS:85144650665
VL - 2
SP - 1090
EP - 1100
JO - Nature Aging
JF - Nature Aging
SN - 2662-8465
IS - 12
ER -