A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome
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A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome. / Scheibye-Knudsen, Morten; Mitchell, Sarah J.; Fang, Evandro F.; Iyama, Teruaki; Ward, Theresa; Wang, James; Dunn, Christopher A.; Singh, Nagendra; Veith, Sebastian; Hasan-Olive, Md Mahdi; Mangerich, Aswin; Wilson, Mark A.; Mattson, Mark P.; Bergersen, Linda H.; Cogger, Victoria C.; Warren, Alessandra; Le Couteur, David G.; Moaddel, Ruin; Wilson, David M.; Croteau, Deborah L.; De Cabo, Rafael; Bohr, Vilhelm A.
In: Cell Metabolism, Vol. 20, No. 5, 04.11.2014, p. 840-855.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome
AU - Scheibye-Knudsen, Morten
AU - Mitchell, Sarah J.
AU - Fang, Evandro F.
AU - Iyama, Teruaki
AU - Ward, Theresa
AU - Wang, James
AU - Dunn, Christopher A.
AU - Singh, Nagendra
AU - Veith, Sebastian
AU - Hasan-Olive, Md Mahdi
AU - Mangerich, Aswin
AU - Wilson, Mark A.
AU - Mattson, Mark P.
AU - Bergersen, Linda H.
AU - Cogger, Victoria C.
AU - Warren, Alessandra
AU - Le Couteur, David G.
AU - Moaddel, Ruin
AU - Wilson, David M.
AU - Croteau, Deborah L.
AU - De Cabo, Rafael
AU - Bohr, Vilhelm A.
PY - 2014/11/4
Y1 - 2014/11/4
N2 - Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). Since dietary interventions can alter neurodegenerative processes, Csbm/m mice were given a high-fat, caloric-restricted, or resveratrol-supplemented diet. High-fat feeding rescued the metabolic, transcriptomic, and behavioral phenotypes of Csbm/m mice. Furthermore, premature aging in CS mice, nematodes, and human cells results from aberrant PARP activation due to deficient DNA repair leading to decreased SIRT1 activity and mitochondrial dysfunction. Notably, β-hydroxybutyrate levels are increased by the high-fat diet, and β-hydroxybutyrate, PARP inhibition, or NAD+ supplementation can activate SIRT1 and rescue CS-associated phenotypes. Mechanistically, CSB can displace activated PARP1 from damaged DNA to limit its activity. This study connects two emerging longevity metabolites, β-hydroxybutyrate and NAD+, through the deacetylase SIRT1 and suggests possible interventions for CS.
AB - Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). Since dietary interventions can alter neurodegenerative processes, Csbm/m mice were given a high-fat, caloric-restricted, or resveratrol-supplemented diet. High-fat feeding rescued the metabolic, transcriptomic, and behavioral phenotypes of Csbm/m mice. Furthermore, premature aging in CS mice, nematodes, and human cells results from aberrant PARP activation due to deficient DNA repair leading to decreased SIRT1 activity and mitochondrial dysfunction. Notably, β-hydroxybutyrate levels are increased by the high-fat diet, and β-hydroxybutyrate, PARP inhibition, or NAD+ supplementation can activate SIRT1 and rescue CS-associated phenotypes. Mechanistically, CSB can displace activated PARP1 from damaged DNA to limit its activity. This study connects two emerging longevity metabolites, β-hydroxybutyrate and NAD+, through the deacetylase SIRT1 and suggests possible interventions for CS.
UR - http://www.scopus.com/inward/record.url?scp=84910132320&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2014.10.005
DO - 10.1016/j.cmet.2014.10.005
M3 - Journal article
C2 - 25440059
AN - SCOPUS:84910132320
VL - 20
SP - 840
EP - 855
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 5
ER -
ID: 172128793