A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

Research output: Contribution to journal › Journal article › Research › peer-review

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A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice. / Petr, Michael A.; Alfaras, Irene; Krawcyzk, Melissa; Bair, Woei Nan; Mitchell, Sarah J.; Morrell, Christopher H.; Studenski, Stephanie A.; Price, Nathan L.; Fishbein, Kenneth W.; Spencer, Richard G.; Scheibye-Knudsen, Morten; Lakatta, Edward G.; Ferrucci, Luigi; Aon, Miguel A.; Bernier, Michel; de Cabo, Rafael.

In: eLife, Vol. 10, e62952, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petr, MA, Alfaras, I, Krawcyzk, M, Bair, WN, Mitchell, SJ, Morrell, CH, Studenski, SA, Price, NL, Fishbein, KW, Spencer, RG, Scheibye-Knudsen, M, Lakatta, EG, Ferrucci, L, Aon, MA, Bernier, M & de Cabo, R 2021, 'A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice', eLife, vol. 10, e62952. https://doi.org/10.7554/ELIFE.62952

APA

Petr, M. A., Alfaras, I., Krawcyzk, M., Bair, W. N., Mitchell, S. J., Morrell, C. H., Studenski, S. A., Price, N. L., Fishbein, K. W., Spencer, R. G., Scheibye-Knudsen, M., Lakatta, E. G., Ferrucci, L., Aon, M. A., Bernier, M., & de Cabo, R. (2021). A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice. eLife, 10, [e62952]. https://doi.org/10.7554/ELIFE.62952

Vancouver

Petr MA, Alfaras I, Krawcyzk M, Bair WN, Mitchell SJ, Morrell CH et al. A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice. eLife. 2021;10. e62952. https://doi.org/10.7554/ELIFE.62952

Author

Petr, Michael A. ; Alfaras, Irene ; Krawcyzk, Melissa ; Bair, Woei Nan ; Mitchell, Sarah J. ; Morrell, Christopher H. ; Studenski, Stephanie A. ; Price, Nathan L. ; Fishbein, Kenneth W. ; Spencer, Richard G. ; Scheibye-Knudsen, Morten ; Lakatta, Edward G. ; Ferrucci, Luigi ; Aon, Miguel A. ; Bernier, Michel ; de Cabo, Rafael. / A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice. In: eLife. 2021 ; Vol. 10.

Bibtex

@article{a7714718ae3c48f0848c2f809fad85dd,
title = "A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice",
abstract = "Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.",
author = "Petr, {Michael A.} and Irene Alfaras and Melissa Krawcyzk and Bair, {Woei Nan} and Mitchell, {Sarah J.} and Morrell, {Christopher H.} and Studenski, {Stephanie A.} and Price, {Nathan L.} and Fishbein, {Kenneth W.} and Spencer, {Richard G.} and Morten Scheibye-Knudsen and Lakatta, {Edward G.} and Luigi Ferrucci and Aon, {Miguel A.} and Michel Bernier and {de Cabo}, Rafael",
note = "Funding Information: This study was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. We are grateful to the Comparative Medicine Section of the NIA, NIH for their exceptional animal care. We thank the NIA Aging Rodent Colony for providing aging mice for this study as part of their aging mouse resource. Publisher Copyright: {\textcopyright} 2021, eLife Sciences Publications Ltd. All rights reserved.",
year = "2021",
doi = "10.7554/ELIFE.62952",
language = "English",
volume = "10",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

AU - Petr, Michael A.

AU - Alfaras, Irene

AU - Krawcyzk, Melissa

AU - Bair, Woei Nan

AU - Mitchell, Sarah J.

AU - Morrell, Christopher H.

AU - Studenski, Stephanie A.

AU - Price, Nathan L.

AU - Fishbein, Kenneth W.

AU - Spencer, Richard G.

AU - Scheibye-Knudsen, Morten

AU - Lakatta, Edward G.

AU - Ferrucci, Luigi

AU - Aon, Miguel A.

AU - Bernier, Michel

AU - de Cabo, Rafael

N1 - Funding Information: This study was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. We are grateful to the Comparative Medicine Section of the NIA, NIH for their exceptional animal care. We thank the NIA Aging Rodent Colony for providing aging mice for this study as part of their aging mouse resource. Publisher Copyright: © 2021, eLife Sciences Publications Ltd. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.

AB - Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.

U2 - 10.7554/ELIFE.62952

DO - 10.7554/ELIFE.62952

M3 - Journal article

C2 - 33876723

AN - SCOPUS:85105298420

VL - 10

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e62952

ER -

ID: 306899535