Myogenic response of human skeletal muscle to 12 weeks of resistance training at light loading intensity
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Myogenic response of human skeletal muscle to 12 weeks of resistance training at light loading intensity. / Mackey, Abigail; Holm, L; Reitelseder, S; Pedersen, T G; Doessing, S; Kadi, F; Kjaer, M.
I: Scandinavian Journal of Medicine & Science in Sports, Bind 21, Nr. 6, 2011, s. 773-82.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Myogenic response of human skeletal muscle to 12 weeks of resistance training at light loading intensity
AU - Mackey, Abigail
AU - Holm, L
AU - Reitelseder, S
AU - Pedersen, T G
AU - Doessing, S
AU - Kadi, F
AU - Kjaer, M
N1 - © 2010 John Wiley & Sons A/S.
PY - 2011
Y1 - 2011
N2 - There is strong evidence for enhanced numbers of satellite cells with heavy resistance training. The satellite cell response to very light muscle loading is, however, unknown. We, therefore, designed a 12-week training protocol where volunteers trained one leg with a high load (H) and the other leg with a light load (L). Twelve young healthy men [mean age 25 ± 3 standard deviation (SD) years] volunteered for the study. Muscle biopsies were collected from the m. vastus lateralis of both legs before and after the training period and satellite cells were visualized by CD56 immunohistochemistry. A significant main effect of time was observed (P<0.001) for the number of CD56+ cells per fiber (L: from 0.11 ± 0.02 to 0.13 ± 0.03; H: from 0.12 ± 0.03 to 0.15 ± 0.05, mean ± SD). The finding that 12 weeks of training skeletal muscle even with very light loads can induce an increase in the number of satellite cells reveals a new aspect of myogenic precursor cell activation and suggests that satellite cells may play a role in skeletal muscle adaptation over a broad physiological range.
AB - There is strong evidence for enhanced numbers of satellite cells with heavy resistance training. The satellite cell response to very light muscle loading is, however, unknown. We, therefore, designed a 12-week training protocol where volunteers trained one leg with a high load (H) and the other leg with a light load (L). Twelve young healthy men [mean age 25 ± 3 standard deviation (SD) years] volunteered for the study. Muscle biopsies were collected from the m. vastus lateralis of both legs before and after the training period and satellite cells were visualized by CD56 immunohistochemistry. A significant main effect of time was observed (P<0.001) for the number of CD56+ cells per fiber (L: from 0.11 ± 0.02 to 0.13 ± 0.03; H: from 0.12 ± 0.03 to 0.15 ± 0.05, mean ± SD). The finding that 12 weeks of training skeletal muscle even with very light loads can induce an increase in the number of satellite cells reveals a new aspect of myogenic precursor cell activation and suggests that satellite cells may play a role in skeletal muscle adaptation over a broad physiological range.
KW - Adult
KW - Antigens, CD56
KW - Biopsy
KW - Denmark
KW - Humans
KW - Male
KW - Muscle Development
KW - Physical Exertion
KW - Quadriceps Muscle
KW - Resistance Training
KW - Satellite Cells, Skeletal Muscle
KW - Young Adult
U2 - 10.1111/j.1600-0838.2010.01178.x
DO - 10.1111/j.1600-0838.2010.01178.x
M3 - Journal article
C2 - 21143306
VL - 21
SP - 773
EP - 782
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 6
ER -
ID: 113412816