EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke
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EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke. / Bassetti, Claudio L A; Randerath, Winfried; Vignatelli, Luca; Ferini-Strambi, Luigi; Brill, Anne-Kathrin; Bonsignore, Maria R; Grote, Ludger; Jennum, Poul; Leys, Didier; Minnerup, Jens; Nobili, Lino; Tonia, Thomy; Morgan, Rebecca; Kerry, Joel; Riha, Renata; McNicholas, Walter T; Papavasileiou, Vasileios.
I: European Respiratory Journal, Bind 55, Nr. 4, 1901104, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke
AU - Bassetti, Claudio L A
AU - Randerath, Winfried
AU - Vignatelli, Luca
AU - Ferini-Strambi, Luigi
AU - Brill, Anne-Kathrin
AU - Bonsignore, Maria R
AU - Grote, Ludger
AU - Jennum, Poul
AU - Leys, Didier
AU - Minnerup, Jens
AU - Nobili, Lino
AU - Tonia, Thomy
AU - Morgan, Rebecca
AU - Kerry, Joel
AU - Riha, Renata
AU - McNicholas, Walter T
AU - Papavasileiou, Vasileios
N1 - The article has been co‐published with permission in the European Respiratory Journal and the European Journal of Neurology. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. Either citation can be used when citing this article. Copyright ©European Academy of Neurology and European Respiratory Society 2020.
PY - 2020
Y1 - 2020
N2 - Sleep disorders are highly prevalent in the general population and may be linked in a bidirectional fashion to stroke, which is one of the leading causes of morbidity and mortality.Four major scientific societies established a task force of experts in neurology, stroke, respiratory medicine, sleep medicine and methodology, to critically evaluate the evidence regarding potential links and the impact of therapy. 13 research questions were evaluated in a systematic literature search using a stepwise hierarchical approach: first, systematic reviews and meta-analyses; second, primary studies post-dating the systematic reviews/meta-analyses. A total of 445 studies were evaluated and 88 included. Statements were generated regarding current evidence and clinical practice.Severe obstructive sleep apnoea (OSA) doubles the risk for incident stroke, especially in young to middle-aged patients. Continuous positive airway pressure (CPAP) may reduce stroke risk, especially in treatment-compliant patients. The prevalence of OSA is high in stroke patients and can be assessed by polygraphy. Severe OSA is a risk factor for recurrence of stroke and may be associated with stroke mortality, while CPAP may improve stroke outcome. It is not clear if insomnia increases stroke risk, while pharmacotherapy of insomnia may increase it. Periodic limb movements in sleep (PLMS), but not restless limb syndrome (RLS), may be associated with an increased risk of stroke. Preliminary data suggest a high frequency of post-stroke insomnia and RLS and their association with a less favourable stroke outcome, while treatment data are scarce.Overall, the evidence base is best for OSA relationship with stroke and supports active diagnosis and therapy. Research gaps remain especially regarding insomnia and RLS/PLMS relationships with stroke.
AB - Sleep disorders are highly prevalent in the general population and may be linked in a bidirectional fashion to stroke, which is one of the leading causes of morbidity and mortality.Four major scientific societies established a task force of experts in neurology, stroke, respiratory medicine, sleep medicine and methodology, to critically evaluate the evidence regarding potential links and the impact of therapy. 13 research questions were evaluated in a systematic literature search using a stepwise hierarchical approach: first, systematic reviews and meta-analyses; second, primary studies post-dating the systematic reviews/meta-analyses. A total of 445 studies were evaluated and 88 included. Statements were generated regarding current evidence and clinical practice.Severe obstructive sleep apnoea (OSA) doubles the risk for incident stroke, especially in young to middle-aged patients. Continuous positive airway pressure (CPAP) may reduce stroke risk, especially in treatment-compliant patients. The prevalence of OSA is high in stroke patients and can be assessed by polygraphy. Severe OSA is a risk factor for recurrence of stroke and may be associated with stroke mortality, while CPAP may improve stroke outcome. It is not clear if insomnia increases stroke risk, while pharmacotherapy of insomnia may increase it. Periodic limb movements in sleep (PLMS), but not restless limb syndrome (RLS), may be associated with an increased risk of stroke. Preliminary data suggest a high frequency of post-stroke insomnia and RLS and their association with a less favourable stroke outcome, while treatment data are scarce.Overall, the evidence base is best for OSA relationship with stroke and supports active diagnosis and therapy. Research gaps remain especially regarding insomnia and RLS/PLMS relationships with stroke.
U2 - 10.1183/13993003.01104-2019
DO - 10.1183/13993003.01104-2019
M3 - Journal article
C2 - 32317355
VL - 55
JO - The European Respiratory Journal
JF - The European Respiratory Journal
SN - 0903-1936
IS - 4
M1 - 1901104
ER -
ID: 261541568