A Clinically Applicable Interactive Micro and Macro-Sleep Staging Algorithm for Elderly and Patients with Neurodegeneration

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

Standard

A Clinically Applicable Interactive Micro and Macro-Sleep Staging Algorithm for Elderly and Patients with Neurodegeneration. / Cesari, Matteo; Christensen, Julie A.E.; Sixel-Doring, Friederike; Muntean, Maria Lucia; Mollenhauer, Brit; Trenkwalder, Claudia; Jennum, Poul; Sorensen, Helge B.D.

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. IEEE, 2019. s. 3649-3652 8856705 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Bind 2019).

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

Harvard

Cesari, M, Christensen, JAE, Sixel-Doring, F, Muntean, ML, Mollenhauer, B, Trenkwalder, C, Jennum, P & Sorensen, HBD 2019, A Clinically Applicable Interactive Micro and Macro-Sleep Staging Algorithm for Elderly and Patients with Neurodegeneration. i 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019., 8856705, IEEE, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, bind 2019, s. 3649-3652, 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019, Berlin, Tyskland, 23/07/2019. https://doi.org/10.1109/EMBC.2019.8856705

APA

Cesari, M., Christensen, J. A. E., Sixel-Doring, F., Muntean, M. L., Mollenhauer, B., Trenkwalder, C., Jennum, P., & Sorensen, H. B. D. (2019). A Clinically Applicable Interactive Micro and Macro-Sleep Staging Algorithm for Elderly and Patients with Neurodegeneration. I 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (s. 3649-3652). [8856705] IEEE. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS Bind 2019 https://doi.org/10.1109/EMBC.2019.8856705

Vancouver

Cesari M, Christensen JAE, Sixel-Doring F, Muntean ML, Mollenhauer B, Trenkwalder C o.a. A Clinically Applicable Interactive Micro and Macro-Sleep Staging Algorithm for Elderly and Patients with Neurodegeneration. I 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. IEEE. 2019. s. 3649-3652. 8856705. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Bind 2019). https://doi.org/10.1109/EMBC.2019.8856705

Author

Cesari, Matteo ; Christensen, Julie A.E. ; Sixel-Doring, Friederike ; Muntean, Maria Lucia ; Mollenhauer, Brit ; Trenkwalder, Claudia ; Jennum, Poul ; Sorensen, Helge B.D. / A Clinically Applicable Interactive Micro and Macro-Sleep Staging Algorithm for Elderly and Patients with Neurodegeneration. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019. IEEE, 2019. s. 3649-3652 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Bind 2019).

Bibtex

@inproceedings{9071da98c9834d04b9c418a9755459a2,
title = "A Clinically Applicable Interactive Micro and Macro-Sleep Staging Algorithm for Elderly and Patients with Neurodegeneration",
abstract = "Elderly and patients with neurodegenerative diseases (NDD) often complain about sleep problems and show altered sleep structure. Automated algorithms for efficient and specific sleep staging are needed. We propose a new algorithm using only one electroencephalographic and two electrooculographic channels to score wakefulness, rapid eye movement (REM) sleep and non-REM sleep in a cohort of elderly healthy controls (HC), patients with Parkinson's disease (PD), isolated REM sleep behavior disorder (iRBD), considered the prodromal stage of PD, and patients with PD and RBD (PD+RBD). The proposed method scores both standard 30-s epochs (macro-staging) and 5-s mini-epochs (micro-staging), whose evaluation may help to better understand sleep micro-structure. Moreover, the algorithm is interactive, as it labels the classified sleep epochs as either certain or uncertain, so that experts can manually review the uncertain ones. The algorithm performances were evaluated for macro-sleep staging, where it achieved overall accuracies of 0.87±0.05 in 41 HC, 0.86±0.10 in 57 PD, 0.76±0.10 in 31 iRBD and 0.77±0.10 in 30 PD+RBD patients when all 30-s epochs were considered. The accuracies increased to 0.91±0.05, 0.90±0.08, 0.85±0.09, 0.88±0.08 respectively when considering only the certain ones. The epochs labeled as uncertain were 9.95±4.15%, 11.13±7.86%, 18.39±7.38% and 18.90±8.00% in HC, PD, iRBD and PD+RBD respectively. The proposed interactive micro and macro sleep staging algorithm can be used in clinics to reduce the burden of manual sleep staging in elderly and patients with NDD.",
author = "Matteo Cesari and Christensen, {Julie A.E.} and Friederike Sixel-Doring and Muntean, {Maria Lucia} and Brit Mollenhauer and Claudia Trenkwalder and Poul Jennum and Sorensen, {Helge B.D.}",
year = "2019",
doi = "10.1109/EMBC.2019.8856705",
language = "English",
isbn = "978-1-5386-1312-2",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
publisher = "IEEE",
pages = "3649--3652",
booktitle = "2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019",
note = "41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 ; Conference date: 23-07-2019 Through 27-07-2019",

}

RIS

TY - GEN

T1 - A Clinically Applicable Interactive Micro and Macro-Sleep Staging Algorithm for Elderly and Patients with Neurodegeneration

AU - Cesari, Matteo

AU - Christensen, Julie A.E.

AU - Sixel-Doring, Friederike

AU - Muntean, Maria Lucia

AU - Mollenhauer, Brit

AU - Trenkwalder, Claudia

AU - Jennum, Poul

AU - Sorensen, Helge B.D.

PY - 2019

Y1 - 2019

N2 - Elderly and patients with neurodegenerative diseases (NDD) often complain about sleep problems and show altered sleep structure. Automated algorithms for efficient and specific sleep staging are needed. We propose a new algorithm using only one electroencephalographic and two electrooculographic channels to score wakefulness, rapid eye movement (REM) sleep and non-REM sleep in a cohort of elderly healthy controls (HC), patients with Parkinson's disease (PD), isolated REM sleep behavior disorder (iRBD), considered the prodromal stage of PD, and patients with PD and RBD (PD+RBD). The proposed method scores both standard 30-s epochs (macro-staging) and 5-s mini-epochs (micro-staging), whose evaluation may help to better understand sleep micro-structure. Moreover, the algorithm is interactive, as it labels the classified sleep epochs as either certain or uncertain, so that experts can manually review the uncertain ones. The algorithm performances were evaluated for macro-sleep staging, where it achieved overall accuracies of 0.87±0.05 in 41 HC, 0.86±0.10 in 57 PD, 0.76±0.10 in 31 iRBD and 0.77±0.10 in 30 PD+RBD patients when all 30-s epochs were considered. The accuracies increased to 0.91±0.05, 0.90±0.08, 0.85±0.09, 0.88±0.08 respectively when considering only the certain ones. The epochs labeled as uncertain were 9.95±4.15%, 11.13±7.86%, 18.39±7.38% and 18.90±8.00% in HC, PD, iRBD and PD+RBD respectively. The proposed interactive micro and macro sleep staging algorithm can be used in clinics to reduce the burden of manual sleep staging in elderly and patients with NDD.

AB - Elderly and patients with neurodegenerative diseases (NDD) often complain about sleep problems and show altered sleep structure. Automated algorithms for efficient and specific sleep staging are needed. We propose a new algorithm using only one electroencephalographic and two electrooculographic channels to score wakefulness, rapid eye movement (REM) sleep and non-REM sleep in a cohort of elderly healthy controls (HC), patients with Parkinson's disease (PD), isolated REM sleep behavior disorder (iRBD), considered the prodromal stage of PD, and patients with PD and RBD (PD+RBD). The proposed method scores both standard 30-s epochs (macro-staging) and 5-s mini-epochs (micro-staging), whose evaluation may help to better understand sleep micro-structure. Moreover, the algorithm is interactive, as it labels the classified sleep epochs as either certain or uncertain, so that experts can manually review the uncertain ones. The algorithm performances were evaluated for macro-sleep staging, where it achieved overall accuracies of 0.87±0.05 in 41 HC, 0.86±0.10 in 57 PD, 0.76±0.10 in 31 iRBD and 0.77±0.10 in 30 PD+RBD patients when all 30-s epochs were considered. The accuracies increased to 0.91±0.05, 0.90±0.08, 0.85±0.09, 0.88±0.08 respectively when considering only the certain ones. The epochs labeled as uncertain were 9.95±4.15%, 11.13±7.86%, 18.39±7.38% and 18.90±8.00% in HC, PD, iRBD and PD+RBD respectively. The proposed interactive micro and macro sleep staging algorithm can be used in clinics to reduce the burden of manual sleep staging in elderly and patients with NDD.

U2 - 10.1109/EMBC.2019.8856705

DO - 10.1109/EMBC.2019.8856705

M3 - Article in proceedings

C2 - 31946667

AN - SCOPUS:85077881438

SN - 978-1-5386-1312-2

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

SP - 3649

EP - 3652

BT - 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019

PB - IEEE

T2 - 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019

Y2 - 23 July 2019 through 27 July 2019

ER -

ID: 241421397