Publikationer 2010 – Københavns Universitet

Videresend til en ven Resize Print Bookmark and Share

Sund Aldring > Publikationer > Videnskabelige publikationer > Publikationer 2010

Publications 2010

The list of publications by scientists from Center for Healthy Aging is only in English as most publications are published in English.

Listen over videnskabelige publikationer af forskere fra Center for Sund Aldring er kun på engelsk, da de fleste publikationer kun bliver offentliggjort på engelsk.

Til toppen Program 1a - Molecular and Cellular: Molecular Aging

Identifying patients with therapy-resistant depression by using factor analysis. Andreasson K, Liest V, Lunde M, Martiny K, Unden M, Dising S, Bech P. 2010 Nov.

INTRODUCTION: Attempts to identify the factor structure in patients with treatment-resistant depression have been very limited. METHODS: Principal component analysis was performed using the baseline datasets from 3 add-on studies [2 with repetitive transcranial magnetic stimulation and one with transcranial pulsed electromagnetic fields (T-PEMF)], in which the relative effect as percentage of improvement during the treatment period was analysed...

See full abstract

Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AM. 2010 Oct.

OBJECTIVE: To investigate the associations between age, gender, systemic diseases, medications and labial and whole salivary flow rates in older people. METHODS: Unstimulated labial (LS) and unstimulated (UWS) and chewing-stimulated (SWS) whole salivary flow rates were measured in 389 randomly selected community-dwelling Danish women and 279 men aged 65-97 years. Systemic diseases, medications (coded according to the Anatomical Therapeutic Chemical (ATC) Classification System), tobacco and alcohol consumption were registered..

See full abstract

Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.Yang JL, Tadokoro T, Keijzers G, Mattson MP, Bohr VA. 2010 Sep 3.

Glutamate, the major excitatory neurotransmitter in the brain, activates receptors coupled to membrane depolarization and Ca(2+) influx that mediates functional responses of neurons including processes such as learning and memory. Here we show that reversible nuclear oxidative DNA damage occurs in cerebral cortical neurons in response to transient glutamate receptor activation using non-toxic physiological levels of glutamate...

See full abstract

Helicobacter pylori infection generates genetic instability in gastric cells. Machado AM, Figueiredo C, Seruca R, Rasmussen LJ. 2010 Aug.

The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells...

See full abstract

The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism. Desler C, Lykke A, Rasmussen LJ. 2010 Aug.

Several enzymes of the metabolic pathways responsible for metabolism of cytosolic ribonucleotides and deoxyribonucleotides are located in mitochondria. Studies described in this paper suggest dysfunction of the mitochondria to affect these metabolic pathways and limit the available levels of cytosolic ribonucleotides and deoxyribonucleotides, which in turn can result in aberrant RNA and DNA synthesis...

See full abstract

BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Chu WK, Hanada K, Kanaar R, Hickson ID. 2010 Aug.

In this study, we report the characterization of mouse embryonic stem cells with disruption of Blm and/or Rad54 genes. We show that Blm has roles both upstream and downstream of the Rad54 protein, a core HR factor...


See full abstract

Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage. Skovgaard T, Rasmussen LJ, Munch-Petersen B. 2010 Jun.

Balanced deoxynucleotide pools are known to be important for correct DNA repair, and deficiency for some of the central enzymes in deoxynucleotide metabolism can cause imbalanced pools, which in turn can lead to mutagenesis and cell death. Here we show that cells deficient for the thymidine salvage enzyme thymidine kinase 1 (TK1) are more resistant to UV-induced DNA damage than TK1 positive cells although they have thymidine triphosphate (dTTP) levels of only half the size of control cells...

See full abstract

VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy. Cao R, Xue Y, Hedlund EM, Zhong Z, Tritsaris K, Tondelli B, Lucchini F, Zhu Z, Dissing S, Cao Y. 2010 Jan.

Here, we show that systemic delivery of VEGF and placental  growth factor (PlGF) by protein implantation, tumors, and adenoviral vectors ablates pericytes from the mature retinal vasculature through the VEGF receptor 1 (VEGFR1)-mediated signaling pathway, leading to increased vascular leakage. In contrast, we demonstrate VEGF receptor 2 (VEGFR2) is primarily expressed in nonvascular photoreceptors and ganglion cells. Moreover, blockade of VEGFR1 but not VEGFR2 significantly restores pericyte saturation in mature retinal vessels...



See full abstract

 

Til toppen Program 1b - Molecular and Cellular: Neurobiology

Glial and neuronal control of brain blood flow. Attwell D, Buchan AM, Charpak S, Lauritzen M, MacVicar BA, Newman EA. 2010 Nov.

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders....

See full abstract

 

Til toppen Program 2 - Molecular and Cellular: Muscle and Matrix

Diminished insulin-mediated forearm blood flow and muscle glucose uptake in young men with low birth weight. Sonne MP, Højbjerre L, Alibegovic AC, Vaag A, Stallknecht B, Dela F. 2010.

Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22)...

See full abstract

Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Helmark IC, Mikkelsen UR, Børglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. 2010.

The microdialysis method was applied to the human knee joint with osteoarthritis (OA) in order to reveal changes in biochemical markers of cartilage and inflammation, intraarticularly and in the synovium, in response to a single bout of mechanical joint loading.

See full abstract

Validation of the Falls Efficacy Scale and Falls Efficacy Scale International in geriatric patients with and without cognitive impairment: results of self-report and interview-based questionnaires. Hauer K, Yardley L, Beyer N, Kempen G, Dias N, Campbell M, Becker C, Todd C. 2010.

Frail, old patients with and without cognitive impairment are at high risk of falls and associated medical and psychosocial issues. The lack of adequate, validated instruments has partly hindered research in this field. So far no questionnaire documenting fall-related self-efficacy/fear of falling has been validated for older persons with cognitive impairment or for different administration methods such as self-report or interview. OBJECTIVE: To validate the self-report and interview version of the Falls Efficacy Scale (FES) and the Falls Efficacy Scale International Version (FES-I) in frail geriatric patients with and without cognitive impairment.

See full abstract

Tensile properties of human collagen fibrils and fascicles are insensitive to environmental salts. Svensson RB, Hassenkam T, Grant CA, Magnusson SP. 2010 Dec.

[I]n this study, we focus on the tensile mechanical properties of two hierarchical levels from human patellar tendon, namely: individual collagen fibrils and fascicles. Investigations on collagen fibrils and fascicles were made at pH 7.4 in solutions of phosphate-buffered saline at three different concentrations as well as two HEPES buffered solutions containing NaCl or NaCl + CaCl2....

See full abstract

Increased cellular proliferation in rat skeletal muscle and tendon in response to exercise: use of FLT and PET/CT. Skovgaard D, Bayer ML, Mackey AL, Madsen J, Kjaer M, Kjaer A. 2010 Dec.

The purpose of this study is to investigate exercise-induced cellular proliferation in rat skeletal muscle/tendon with the use of 3'-[F-18]fluoro-3'deoxythymidine (FLT) and to quantitatively study concomitant changes in the proliferation-associated factor, Ki67...

See full abstract

Distribution of myogenic progenitor cells and myonuclei is altered in women with vs. those without chronically painful trapezius muscle. Mackey AL, Andersen LL, Frandsen U, Suetta C, Sjøgaard G. 2010 Dec.

This study investigated the distribution of satellite cells (SCs), myonuclei, and macrophages in muscle biopsies from the trapezius muscle of 42 women performing repetitive manual work, diagnosed with trapezius myalgia (MYA; 44 ± 8 yr; mean ± SD) and 20 matched healthy controls (CON; 45 ± 9 yr). Our hypothesis was that muscle of MYA, in particular type I fibers, would demonstrate higher numbers of SCs, myonuclei, and macrophages compared with CON...

See full abstract

Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining. Hvid L, Aagaard P, Justesen L, Bayer ML, Andersen JL, Ørtenblad N, Kjaer M, Suetta C. 2010 Dec.

Very little attention has been given to the combined effects of aging and disuse as separate factors causing deterioration in muscle mechanical function. Thus the purpose of this study was to investigate the effects of 2 wk of immobilization followed by 4 wk of retraining on knee extensor muscle mechanical function (e.g., maximal strength and rapid force capacity) and muscle fiber morphology in 9 old (OM: 67.3 ± 1.3 yr) and 11 young healthy men (YM: 24.4 ± 0.5 yr) with comparable levels of physical activity....

See full abstract

Skeletal muscle myofibrillar and sarcoplasmic protein synthesis rates are affected differently by altitude-induced hypoxia in native lowlanders. Holm L, Haslund ML, Robach P, van Hall G, Calbet JA, Saltin B, Lundby C. 2010 Dec.

As a consequence to hypobaric hypoxic exposure skeletal muscle atrophy is often reported. The underlying mechanism has been suggested to involve a decrease in protein synthesis in order to conserve O(2). With the aim to challenge this hypothesis, we applied a primed, constant infusion of 1-(13)C-leucine in nine healthy male subjects at sea level and subsequently at high-altitude (4559 m) after 7-9 days of acclimatization....

See full abstract

GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients. Doessing S, Holm L, Heinemeier KM, Feldt-Rasmussen U, Schjerling P, Qvortrup K, Larsen JO, Nielsen RH, Flyvbjerg A, Kjaer M. 2010 Dec.

We hypothesized that the local production of collagen is associated with the level of GH/IGF1.DESIGN AND METHODS: As primary outcomes, collagen mRNA expression and collagen protein fractional synthesis rate (FSR) were determined locally in skeletal muscle and tendon in nine ACRO and nine GHD patients. Moreover, muscle myofibrillar protein synthesis and tendon collagen morphology were determined...


See full abstract 

Intermuscular force transmission between human plantar flexor muscles in vivo. Boejsen-Moeller J, Schwartz S, Kalliokoski K, Finni T, Magnusson SP. 2010 Dec.

The exact mechanical function of synergist muscles within a human limb in vivo is not well described. Recent studies indicate the existence of a mechanical interaction between muscle actuators that may have functional significance and further play a role for injury mechanisms. The purpose of the present study was to investigate if intermuscular force transmission occurs within and between human plantarflexor muscles in vivo...

See full abstract

Impact of physical inactivity on subcutaneous adipose tissue metabolism in healthy young male offspring of patients with type 2 diabetes. Højbjerre L, Sonne MP, Alibegovic AC, Dela F, Vaag A, Meldgaard JB, Christensen KB, Stallknecht B. 2010 Nov.

OBJECTIVE: Physical inactivity is a risk factor for type 2 diabetes and may be more detrimental in first-degree relative (FDR) subjects, unmasking underlying defects of metabolism. Using a positive family history of type 2 diabetes as a marker of increased genetic risk, the aim of this study was to investigate the impact of physical inactivity on adipose tissue (AT) metabolism in FDR subjects...

See full abstract

Early osteoarthritis and microdialysis: a novel in vivo approach for measurements of biochemical markers in the perisynovium and intraarticularly. Helmark IC, Mikkelsen UR, Krogsgaard MR, Belhage B, Petersen MC, Langberg H, Kjaer M. 2010 Nov.

The microdialysis technique was evaluated as a possible method to obtain local measurements of biochemical markers from knee joints with degenerative changes. Seven patients scheduled for arthroscopy of the knee due to minor to moderate degenerative changes had microdialysis catheters inserted under ultrasonographic guidance, intraarticularly and in the synovium-close tissue....

See full abstract

Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men. Alibegovic A.C., Sonne, M.P., Højbjerre, L., Borl-Jensen, J., Jacobsen, S., Nilsson, E., Færch, K., Hiscock, N.J., Mortensen, B., Friedrichsen, M., Stallknecht, B., Dela, F., Vaag, A. 2010 Nov.

Physical inactivity is a risk factor for insulin resistance. We examined the effect of 9 days of bed rest on basal and insulin-stimulated expression of genes potentially involved in insulin action by applying hypothesis-generating microarray in parallel with candidate gene real-time PCR approaches in 20 healthy young men...

See full abstract

Hip abduction strength training in the clinical setting: with or without external loading? Thorborg K, Bandholm T, Petersen J, Weeke KM, Weinold C, Andersen B, Serner A, Magnusson SP, Hölmich P. 2010 Oct.

The side-lying hip abduction exercise is one of the most commonly used exercises in rehabilitation to increase hip abduction strength, and is often performed without external loading. The aim of this study was to compare the effect of 6 weeks of side-lying hip abduction training, with and without external loading, on hip abduction strength in healthy subjects...

See full abstract

Intake of total dietary sugar and fibre is associated with insulin resistance among Danish 8-10- and 14-16-year-old girls but not boys. European Youth Heart Studies I and II. Kynde I, Johnsen NF, Wedderkopp N, Bygbjerg IB, Helge JW, Heitmann BL. 2010 Oct.

OBJECTIVE: To examine the dietary intake of total sugar, added sugar, non-added sugar and starch as well as dietary fibre and glycaemic index (GI) and their respective associations with insulin resistance. DESIGN: Mixed linear models were used to study both cross-sectional and prospective associations between carbohydrate components and insulin resistance separately in girls and boys. Diet was assessed by a single 24 h recall interview and insulin resistance was calculated using the homoestasis model assessment (HOMA)...

See full abstract

Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes. Rabøl R, Boushel R, Almdal T, Hansen CN, Ploug T, Haugaard SB, Prats C, Madsbad S, Dela F. 2010 Sep.

AIM: Skeletal muscle insulin resistance has been linked to mitochondrial dysfunction. We examined how improvements in muscular insulin sensitivity following rosiglitazone (ROSI) or pioglitazone (PIO) treatment would affect muscle mitochondrial function in patients with type 2 diabetes mellitus (T2DM)...

See full abstract

Measuring protein breakdown rate in individual proteins in vivo. Holm L, Kjaer M. 2010 Sep.

PURPOSE OF REVIEW: To outline different approaches of how protein breakdown can be quantified and to present a new approach to determine the fractional breakdown rate of individual slow turnover proteins in vivo.

See full abstract

Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes. Hey-Mogensen M, Højlund K, Vind BF, Wang L, Dela F, Beck-Nielsen H, Fernström M, Sahlin K. 2010 Sep.

AIM/HYPOTHESIS: Studies have suggested a link between insulin resistance and mitochondrial dysfunction in skeletal muscles. Our primary aim was to investigate the effect of aerobic training on mitochondrial respiration and mitochondrial reactive oxygen species (ROS) release in skeletal muscle of obese participants with and without type 2 diabetes....

See full abstract

Arm and leg substrate utilization and muscle adaptation after prolonged low-intensity training. Helge JW. 2010 Aug.

This review will focus on current data where substrate metabolism in arm and leg muscle is investigated and discuss the presence of higher carbohydrate oxidation and lactate release observed during arm compared with leg exercise. Furthermore, a basis for a possible difference in substrate partitioning between endogenous and exogenous substrate during arm and leg exercise will be debated. Moreover the review will probe if differences between arm and leg muscle are merely a result of different training status rather than a qualitative difference in limb substrate regulation...

See full abstract

Muscle ceramide content in man is higher in type I than type II fibers and not influenced by glycogen content. Nordby P, Prats C, Kristensen D, Ekroos K, Forsberg G, Andersen JL, Ploug T, Dela F, Storlien L, Helge JW. 2010 Jul.

Human muscle is studied during glycogen depletion and repletion to understand the influence of exercise and muscle glycogen on total ceramide content. In addition, fiber-type-specific ceramide storage is investigated. Ten healthy males (26.4 +/- 0.9 years, BMI 24.4 +/- 0.7 kg m(-2) and VO2max 57 +/- 2 mL O2 min(-1) kg(-1)) participated in the study...

See full abstract

Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia. Heinonen IH, Kemppainen J, Kaskinoro K, Peltonen JE, Borra R, Lindroos M, Oikonen V, Nuutila P, Knuuti J, Boushel R, Kalliokoski KK. 2010 Jul.

Although many effects of both acute and chronic hypoxia on the circulation are well characterized, the distribution and regulation of blood flow (BF) heterogeneity in skeletal muscle during systemic hypoxia is not well understood in humans. We measured muscle BF within the thigh muscles of nine healthy young men using positron emission tomography during one-leg dynamic knee extension exercise in normoxia and moderate physiological systemic hypoxia (14% O(2) corresponding to approximately 3,400 m of altitude) without and with local adenosine receptor inhibition with femoral artery infusion of aminophylline...

See full abstract

Effect of physical training on insulin secretion and action in skeletal muscle and adipose tissue of first-degree relatives of type 2 diabetic patients. Dela F, Stallknecht B. 2010 Jul.

Physical training affects insulin secretion and action, but there is a paucity of data on the direct effects in skeletal muscle and adipose tissue and on the effect of training in first-degree relatives (FDR) of patients with type 2 diabetes. We studied insulin action at the whole body level and peripherally in skeletal muscle and adipose tissue as well as insulin-secretory capacity in seven FDR and eight control (CON) subjects before and after 12 wk of endurance training....


See full abstract

Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. Kraunsøe R, Boushel R, Hansen CN, Schjerling P, Qvortrup K, Støckel M, Mikines KJ, Dela F. 2010 Jun.

Adipose tissue exerts important endocrine and metabolic functions in health and disease. Yet the bioenergetics of this tissue is not characterized in humans and possible regional differences are not elucidated. Using high resolution respirometry, mitochondrial respiration was quantified in human abdominal subcutaneous and intra-abdominal visceral (omentum majus) adipose tissue from biopsies obtained in 20 obese patients undergoing bariatric surgery....

See full abstract

FAT/CD36 is localized in sarcolemma and in vesicle-like structures in subsarcolemma regions but not in mitochondria. Jeppesen J, Mogensen M, Prats C, Sahlin K, Madsen K, Kiens B. 2010 Jun.

The primary aim of the present study was to investigate in which cellular compartments fatty acid trans-locase CD36 (FAT/CD36) is localized. Intact and fully functional skeletal muscle mitochondria were isolated from lean and obese female Zucker rats and from 10 healthy male individuals...

See full abstract

The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension. Bayer ML, Yeung CY, Kadler KE, Qvortrup K, Baar K, Svensson RB, Magnusson SP, Krogsgaard M, Koch M, Kjaer M. 2010 Jun.

Tendon fibroblasts synthesize collagen and form fibrils during embryonic development, but to what extent mature fibroblasts are able to recapitulate embryonic development and develop normal tendon structure is unknown. The present study examined the capability of mature human tendon fibroblasts to initiate collagen fibrillogenesis when cultured in fixed-length fibrin gels...

See full abstract

Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation. Axelsen LN, Lademann JB, Petersen JS, Holstein-Rathlou NH, Ploug T, Prats C, Pedersen HD, Kjølbye AL. 2010 Jun.

Metabolic syndrome and obesity-related diseases are affecting more and more people in the Western world. The basis for an effective treatment of these patients is a better understanding of the underlying pathophysiology. Here, we characterize fructose- and fat-fed rats (FFFRs) as a new animal model of metabolic syndrome. Sprague-Dawley rats were fed a 60 kcal/100 kcal fat diet with 10% fructose in the drinking water...

See full abstract

Fat oxidation at rest predicts peak fat oxidation during exercise and metabolic phenotype in overweight men. Rosenkilde M, Nordby P, Nielsen LB, Stallknecht BM, Helge JW. 2010 May.

OBJECTIVE: To elucidate if fat oxidation at rest predicts peak fat oxidation during exercise and/or metabolic phenotype in moderately overweight, sedentary men. 

See full abstract

The pathogenesis of tendinopathy: balancing the response to loading. Magnusson SP, Langberg H, Kjaer M. 2010 May.

Despite the ability of tendons to adapt to loading, repetitive use often results in injuries, such as tendinopathy, which is characterized by pain during activity, localized tenderness upon palpation, swelling and impaired performance...

See full abstract

Childhood hypo-adiponectinaemia but not hyper-leptinaemia is associated with insulin insensitivity 6 years later. Kynde I, Heitmann BL, Bygbjerg IC, Andersen LB, Helge JW.2010 May.

BACKGROUND: Biomarkers of metabolism and inflammation may predict children with increased diabetes risk.
OBJECTIVE: To study plasma adiponectin, leptin, IL-8, and hepatocyte growth factor (HGF) in childhood and their independent associations with insulin insensitivity, cross-sectional and in 6-yr prospective....

See full abstract

Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. 2010 Apr.

Phospholipase C (PLC) isozymes are key signaling proteins downstream of many extracellular stimuli. Here we show that naive human T cells had very low expression of PLC-gamma1 and that this correlated with low T cell antigen receptor (TCR) responsiveness in naive T cells...

See full abstract

Muscle function and postural balance in lifelong trained male footballers compared with sedentary elderly men and youngsters. Sundstrup E, Jakobsen MD, Andersen JL, Randers MB, Petersen J, Suetta C, Aagaard P, Krustrup P. 2010 Apr.

The present study investigated whether elderly subjects exposed to lifelong football training have better rapid muscle force characteristics, body composition and postural stability in comparison with untrained elderly....

See full abstract

Coordinated increase in skeletal muscle fiber area and expression of IGF-I with resistance exercise in elderly post-operative patients. Suetta C, Clemmensen C, Andersen JL, Magnusson SP, Schjerling P, Kjaer M. 2010 Apr.

Hypertrophy of developing skeletal muscle involves stimulation by insulin-like growth factor-I (IGF-I), however, the role of IGF-I in adult muscle is less clarified. In the present study, the mRNA splice variants of IGF-I (IGF-IEa and MGF) and the changes in muscle fiber cross sectional area after 12 weeks of training were studied in elderly post-operative patients...

See full abstract

Effect of 10 days of bed rest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes. Sonne MP, Alibegovic AC, Højbjerre L, Vaag A, Stallknecht B, Dela F. 2010 Apr.

Physical inactivity is a known risk factor for type 2 diabetes. We studied whole body and forearm insulin sensitivity in subjects at increased risk for type 2 diabetes [persons with low birth weight (LBW group; n = 20) and first-degree relatives to type 2 diabetic patients (FDR group; n = 13)] as well as a control (CON) group (n = 20) matched for body mass index, age, and physical activity levels before and after 10 days of bed rest...

See full abstract

Fibril morphology and tendon mechanical properties in patellar tendinopathy: effects of heavy slow resistance training. Kongsgaard M, Qvortrup K, Larsen J, Aagaard P, Doessing S, Hansen P, Kjaer M, Magnusson SP. 2010 Apr.

BACKGROUND: Patellar tendinopathy is characterized by pathologic abnormalities. Heavy slow resistance training (HSR) is effective in the management of patellar tendinopathy, but the underlying functional mechanisms remain elusive.
PURPOSE: To investigate fibril morphology and mechanical properties in patellar tendinopathy and the effect of HSR on these properties...

See full abstract

The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. Alibegovic AC, Sonne MP, Højbjerre L, Hansen T, Pedersen O, Van Hall G, Holst JJ, Stallknecht B, Dela F, Vaag A. 2010 Apr.

OBJECTIVE:The aim of this study was to determine whether the type 2 diabetes-associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin resistance induced by bed rest...

See full abstract

Time trends in physical activity in leisure time in the Danish population from 1987 to 2005. Petersen CB, Thygesen LC, Helge JW, Grønbaek M, Tolstrup JS. 2010 Mar.

AIMS: To examine time trends in leisure-time physical activity in the Danish population from 1987 to 2005. METHODS: Analyses were based on four national representative population surveys of 4752 respondents in 1987, 4667 in 1994, 16,688 in 2000, and 14,566 in 2005....

See full abstract

Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle. Nielsen J, Mogensen M, Vind BF, Sahlin K, Højlund K, Schrøder HD, Ortenblad N. 2010 Mar.

The purpose of the study was to investigate the effect of aerobic training and type 2 diabetes on intramyocellular localization of lipids, mitochondria, and glycogen. Obese type 2 diabetic patients (n = 12) and matched obese controls (n = 12) participated in aerobic cycling training for 10 wk. Endurance-trained athletes (n = 15) were included for comparison...

See full abstract

Increased rate of whole body lipolysis before and after nine days of bed rest in healthy young men born with low birth weight. Alibegovic A.C., Højbjerre, L., Sonne, M., Hall, G. van, Alsted, T.J., Kiens, B., Stallknecht, B., Dela, F., Vaag, A. 2010 Mar.

Individuals born with low birth weight (LBW) are at risk of developing type 2 diabetes mellitus (T2D), which may be precipitated by physical inactivity. Twenty-two LBW subjects and twenty-three controls were studied before and after bed rest by the hyperinsulinemic euglycemic clamp combined with indirect calorimetry and infusion of stable isotope tracers and preceded by an intravenous glucose tolerance test...

See full abstract

Regional anatomic differences in skeletal muscle mitochondrial respiration in type 2 diabetes and obesity. Rabøl R, Larsen S, Højberg PM, Almdal T, Boushel R, Haugaard SB, Andersen JL, Madsbad S, Dela F. 2010 Feb.

Previous studies on leg skeletal musculature have demonstrated mitochondrial dysfunction associated with type 2 diabetes mellitus (T2DM), but it is not known whether mitochondrial dysfunction is present in the upper extremities. Objective: The aim of the study was to compare mitochondrial respiration and markers of mitochondrial content in skeletal muscle of arm and leg in patients with T2DM and obese control subjects...

See full abstract

A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise. Paulsen G, Egner IM, Drange M, Langberg H, Benestad HB, Fjeld JG, Hallén J, Raastad T. 2010 Feb.

The aim of this study was to investigate the effect of a cyclooxygenase (COX)-2 inhibitor on the recovery of muscle function, inflammation, regeneration after, and adaptation to, unaccustomed eccentric exercise. Thirty-three young males and females participated in a double-blind, placebo-controlled experiment. Seventy unilateral, voluntary, maximal eccentric actions with the elbow flexors were performed twice (bouts 1 and 2) with the same arm, separated by 3 weeks...

See full abstract

Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle. Holm L, van Hall G, Rose AJ, Miller BF, Doessing S, Richter EA, Kjaer M. 2010 Feb.

Exercise stimulates muscle protein fractional synthesis rate (FSR), but the importance of contractile intensity and whether it interplays with feeding is not understood. This was investigated following two distinct resistance exercise (RE) contraction intensities using an intrasubject design in the fasted (n = 10) and fed (n = 10) states...

See full abstract

Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity. Heinonen I, Kemppainen J, Kaskinoro K, Peltonen JE, Borra R, Lindroos MM, Oikonen V, Nuutila P, Knuuti J, Hellsten Y, Boushel R, Kalliokoski KK. 2010 Feb.

In the present study, we measured thigh muscle capillary nutritive blood flow in nine healthy young men using PET at rest and during the femoral artery infusion of adenosine (1 mg min(-1) l thigh volume(-1)), which has previously been shown to induce a maximal whole thigh blood flow of approximately 8 l/min. This response was compared with the blood flow induced by moderate- to high-intensity one-leg dynamic knee extension exercise...

See full abstract

Role of the nervous system in sarcopenia and muscle atrophy with aging - training as a countermeasure. Aagaard P, Suetta C, Magnusson SP, Kjaer M. 2010 Feb.

The impairment in muscle mechanical function is accompanied and partly caused by an age-related loss in neuromuscular function that comprise changes in maximal MN firing frequency, agonist muscle activation, antagonist muscle coactivation, force steadiness, and spinal inhibitory circuitry. Strength training appears to elicit effective countermeasures in elderly individuals even at a very old age (>80 years) by evoking muscle hypertrophy along with substantial changes in neuromuscular function, respectively...

See full abstract

Viscoelastic behavior of discrete human collagen fibrils. Svensson RB, Hassenkam T, Hansen P, Peter Magnusson S. 2010 Jan.

In the present work an atomic force microscopy (AFM) approach was used for tensile testing of two human patellar tendon fibrils. Fibrils were obtained from intact human fascicles, without any pre-treatment besides frozen storage. In the dry state a single isolated fibril was anchored to a substrate using epoxy glue, and the end of the fibril was glued on to an AFM cantilever for tensile testing. In phosphate buffered saline, cyclic testing was performed in the pre-yield region at different strain rates, and the elastic response was determined by a stepwise stress relaxation test...

See fuld abstract

Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M. 2010 Jan.

OBJECTIVE: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo...

See full abstract

Lower strength of the human posterior patellar tendon seems unrelated to mature collagen cross-linking and fibril morphology. Hansen P, Haraldsson BT, Aagaard P, Kovanen V, Avery NC, Qvortrup K, Larsen JO, Krogsgaard M, Kjaer M, Peter Magnusson S. 2010 Jan.

We hypothesized that changes in fibril morphology and collagen cross-linking would parallel differences in material strength between the anterior and posterior tendon. Tendon fascicles were obtained from elective ACL surgery patients and tested micromechanically. Transmission electron microscopy was used to assess fibril morphology, and collagen cross-linking was determined by HPLC and calorimetry...

See full abstract

Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis. Doessing S, Heinemeier KM, Holm L, Mackey AL, Schjerling P, Rennie M, Smith K, Reitelseder S, Kappelgaard AM, Rasmussen MH, Flyvbjerg A, Kjaer M. 2010 Jan.

To test the hypothesis that GH promotes matrix collagen synthesis in musculotendinous tissue, we investigated the effects of 14 day administration of 33-50 microg kg(-1) day(-1) recombinant human GH (rhGH) in healthy young individuals. rhGH administration caused an increase in serum GH, serum IGF-I, and IGF-I mRNA expression in tendon and muscle. Tendon collagen I mRNA expression and tendon collagen protein synthesis increased by 3.9-fold and 1.3-fold, respectively (P < 0.01 and P = 0.02), and muscle collagen I mRNA expression and muscle collagen protein synthesis increased by 2.3-fold and 5.8-fold, respectively (P < 0.01 and P = 0.06).....

See full abstract

 

Til toppen Program 3 - Body and Life

Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. Johannsen TH, Ripa CP, Carlsen E, Starup J, Nielsen OH, Schwartz M, Drzewiecki KT, Mortensen EL, Main KM. 2010.

Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery...

See full abstract

Time limited psychodynamic group therapy. Jensen HH, Mortensen EL, Lotz M. 2010 Dec.

We explore predictors of participation in additional treatment within one year after termination of 39 sessions of psychodynamic group therapy (n=130)....

Excess mortality rate during adulthood among Danish adoptees. Petersen L, Sørensen TI, Mortensen EL, Andersen PK. 2010 Dec.

The aim was to investigate whether the cohort of domestic adoptees used for these studies in Denmark is similar to the general population with respect to all-cause mortality and cause-specific mortality rates...

See full abstract

A cohort study of leisure time physical activity and depression. Mikkelsen SS, Tolstrup JS, Flachs EM, Mortensen EL, Schnohr P, Flensborg-Madsen T. 2010 Dec.

OBJECTIVE: The objective of the study was to examine the role of leisure time physical activity on the risk of developing depression in a large longitudinal setting. METHODS: A prospective cohort study was used, comprising three updated measures of leisure time physical activity and covariates and 26 years of follow-up data on 18,146 individuals from the Copenhagen City Heart Study, Denmark... 

See full abstract

Are negative aspects of social relations predictive of angina pectoris? A 6-year follow-up study of middle-aged Danish women and men. Lund R, Rod NH, Christensen U. 2010 Dec.

During a 6-year follow-up, the authors aimed to assess if negative aspects of social relations were associated with angina pectoris among 4573 middle-aged Danish men and women free of heart disease at baseline in 2000...

See full abstract

Sun protective behaviour in renal transplant recipients. A qualitative study based on individual interviews and the Health Belief Model. Skiveren J, Mortensen EL, Haedersdal M. 2010 Nov.

BACKGROUND: Renal transplant recipients (RTRs) are at high-risk of developing aggressive and potentially lethal non-melanoma skin cancer, which emphasizes the need for consistent sun protective behaviour. OBJECTIVE: To identify factors that exert an influence on the sun protective behaviour of RTRs....

See full Abstract

Early identification of non-remission in first-episode psychosis in a two-year outcome study. Simonsen E, Friis S, Opjordsmoen S, Mortensen EL, Haahr U, Melle I, Joa I, Johannessen JO, Larsen TK, Røssberg JI, Rund BR, Vaglum P, McGlashan TH. 2010 Nov.

OBJECTIVE: To identify predictors of non-remission in first-episode, non-affective psychosis.METHOD: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years

See full abstract

Preventive home visits to older home-dwelling people in Denmark: are invitational procedures of importance? Ekmann A, Vass M, Avlund K. 2010 Nov.

Since 1998 all municipalities in Denmark have been required by law to offer two annual preventive home visits to all home-dwelling citizens aged 75 or over. The influence of invitational procedures on acceptance rates has not been investigated. The aim of this study was to describe and investigate whether different invitational procedures were associated with first preventive home visit acceptance rates....

See full abstract

Late mental health changes in tortured refugees in multidisciplinary treatment. Carlsson JM, Olsen DR, Kastrup M, Mortensen EL. 2010 Nov.

The aim of this study was to examine long-term changes in symptoms of post-traumatic stress disorder, depression, anxiety, and in health-related quality of life in traumatized refugees 23 months after admission to multidisciplinary treatment. The study group comprised 45 persons admitted to the Rehabilitation and Research Centre for Torture Victims in 2001 to 2002....

See full abstract

Mobility disability in midlife: a longitudinal study of the role of anticipated instrumental support and social class. Nilsson CJ, Avlund K, Lund R. 2010 Oct.

On the basis of the evidence of a protective effect of social support on the functional ability of older people and social inequalities in mobility the present study aims to (1) study if onset of mobility disability in a middle-aged cohort is associated with social class and (2) study if anticipation of instrumental support has a protective effect on mobility at 6-year follow-up, and whether this effect is modified by social class....

See full abstract

The importance of individual preferences when evaluating the associations between working hours and indicators of health and well-being. Nabe-Nielsen K, Kecklund G, Ingre M, Skotte J, Diderichsen F, Garde AH. 2010 Oct.

Previous studies indicate that the effect of a given shift schedule may depend on individual factors. The aim of the present study was to investigate whether a misfit between individual preferences and actual working hours affected the association between working hours and self-reported indicators of health and well-being...

See full abstract

Deficient maturation of aspects of attention and executive functions in early onset schizophrenia. Jepsen JR, Fagerlund B, Pagsberg AK, Christensen AM, Nordentoft M, Mortensen EL. 2010 Oct.

The current 5-year follow-up study compared the development of specific cognitive functions in EOS patients (N = 17) from the time of first-episode to chronic phase with that of healthy controls (N = 38) and secondarily to patients with other early onset, non-organic, non-affective psychoses (EOP) (N = 11)...

See full abstract

Occupational position and its relation to mental distress in a random sample of Danish residents. Rugulies R, Madsen IE, Nielsen MB, Olsen LR, Mortensen EL, Bech P. 2010 Aug.

PURPOSE: To analyze the distribution of depressive, anxiety, and somatization symptoms across different occupational positions in a random sample of Danish residents. METHODS: The study sample consisted of 591 Danish residents (50% women), aged 20-65, drawn from an age- and gender-stratified random sample of the Danish population....

See full abstract

Premorbid IQ and adult schizophrenia spectrum disorder: verbal Performance subtests. Sørensen HJ, Mortensen EL, Schiffman J, Ekstrøm M, Denenney D, Mednick SA. 2010 Jun.

The present prospective high-risk study examined associations between childhood scores on five Wechsler Intelligence Scale for Children (WISC) subtests (vocabulary, similarities, block design, object assembly, and mazes) and later development of schizophrenia spectrum disorders (SSD). The sample comprised 244 high-risk or control children who were administered the WISC subtests at age 10 to 13 years in 1972...

See full abstract

Social inequality in onset of mobility disability among older danes: the mediation effect of social relations.Nilsson CJ, Avlund K, Lund R. 2010 Jun.

OBJECTIVE: This article investigates social inequality in onset of mobility disability and in measures of social relations and whether social relations mediated the effect of socioeconomic status on mobility. METHOD: A total of 2,825 nondisabled older men and women, enrolled in the Danish Intervention Study on Preventive Home Visits, constituted the study population...

See full abstract

Early developmental milestones and risk of schizophrenia: a 45-year follow-up of the Copenhagen Perinatal Cohort. Sørensen HJ, Mortensen EL, Schiffman J, Reinisch JM, Maeda J, Mednick SA. 2010 May.

The aim of the present study was to investigate the relationship between age of neuromotor milestone attainment and risk of adult schizophrenia. 5765 mothers of the Copenhagen Perinatal Cohort recorded 12 developmental milestones during the child's first year of life. Cohort members were followed until they were 46-48 years old through record linkage with the Danish Psychiatric Central Research Register...

See full abstract

Can the higher risk of disability onset among older people who live alone be alleviated by strong social relations? A longitudinal study of non-disabled men and women. Lund R, Nilsson CJ, Avlund K. 2010 May.

PURPOSE: to investigate if the increased risk of disability onset among older people who live alone could possibly be moderated by either high social participation or by being satisfied with the social relations. DESIGN AND METHODS: logistic regression models were tested using two waves in a study population of 2,697 non-disabled older men and women from The Danish Longitudinal Study on Preventive Home Visits..

See full abstract

Education reduces the effects of genetic susceptibilities to poor physical health. Johnson W, Kyvik KO, Mortensen EL, Skytthe A, Batty GD, Deary IJ. 2010 Apr.

Greater education is associated with better physical health. This has been of great concern to public health officials. Most demonstrations show that education influences mean levels of health. Little is known about the influence of education on variance in health status, or about how this influence may impact the underlying genetic and environmental sources of health problems. This study explored these influences...

See full abstract

Course of intelligence deficits in early onset, first episode schizophrenia: a controlled, 5-year longitudinal study. Jepsen JR, Fagerlund B, Pagsberg AK, Christensen AM, Hilker RW, Nordentoft M, Mortensen EL. 2010 Apr.

The objective of the current study was to compare the development of intelligence in EOS patients (N = 10) from their first psychotic episode to 5 years of post onset with that of healthy controls (N = 35) and patients who at baseline had been diagnosed with other non-affective psychoses (N = 8)...

See full Abstract

Effectiveness of short-term psychodynamic group therapy in a public outpatient psychotherapy unit. Jensen HH, Mortensen EL, Lotz M. 2010 Apr.

BACKGROUND: Short-term psychodynamic group therapy in heterogeneous patient groups is common in the public Danish psychiatric system but is in need of evaluation. AIM: To investigate improvement in 39-session psychodynamic group therapy using three criteria: 1) effect size (Cohen's d), 2) statistically reliable improvement, and 3) clinical significant change (CSC)...

See full abstract

Fatigue in older adults: an early indicator of the aging process? Avlund K. 2010 Apr.

The aim of this paper is to give an overview of research on fatigue in older adults, with a focus on fatigue as an early indicator of the aging process. Fatigue is a strong predictor of functional limitations, disability, mortality, and other adverse outcomes in young-old and old-old populations, between men and women, and in different geographic localities...

See full abstract

Late introduction of complementary feeding, rather than duration of breastfeeding, may protect against adult overweight. Schack-Nielsen L, Sørensen TIa, Mortensen EL, Michaelsen KF. 2010 Mar.

BACKGROUND: Early nutrition may affect the risk of overweight in later life. OBJECTIVE: The objective was to explore the effect of the duration of breastfeeding (BF) and age at introduction of complementary feeding (CF) on body mass index (BMI) during childhood through adulthood...

See full abstract

Emotional distress and quality of life in relatives of patients with severe brain injury: the first month after injury. Norup A, Siert L, Lykke Mortensen E. 2010 Feb.

PRIMARY OBJECTIVE: To investigate emotional distress and quality of life in a sample of Danish relatives of patients with severe brain injury at admission to intensive rehabilitation in the sub-acute phase...

See full abstract

Integration of healthcare rehabilitation in chronic conditions. Frølich A, Høst D, Schnor H, Nørgaard A, Ravn-Jensen C, Borg E, Hendriksen C. 2010 Feb.

Three entities-Bispebjerg University Hospital, the City of Copenhagen, and the GPs in Copenhagen-collaborated on a quality improvement project focusing on integration and implementation of rehabilitation programmes in four conditions...

See full abstract

Gestational weight gain in relation to offspring body mass index and obesity from infancy through adulthood. Schack-Nielsen L, Michaelsen KF, Gamborg M, Mortensen EL, Sørensen TI. 2010 Jan.

We analyzed whether this effect persists into adulthood and is mediated by effects in childhood.DESIGN: The design of the study a prospective birth cohort study established in 1959-1961. SUBJECTS: The subjects were offspring (n = 4234 of whom 2485 had information from the last follow-up) of mothers included in 'The Copenhagen Perinatal Cohort' during pregnancy or at birth...

See full abstract

 

Til toppen Program 4 - Society and Culture

Sexede seniorer. Opgør med et tabuiseret felt. Oxlund B. 2010 Oct.

Aldring og seksualitet er begreber, der sjældent optræder i samme sætning. Det skyldes, at ældre menneskers seksuelle aktivitet længe har været et tabuiseret felt...

Time for me to be told off - On putting care into words. (Nu skal jeg ind og have skældud: Om at sætte ord på omsorg). Ludvigsen B, Overgaard Mogensen H. 2010 Apr.

The article throws new light on care and dialogue using the analytical term ''relatedness". Discussion of how to create social relatedness is another way of talking about something akin to what nurses already do, and are aware of, but which they call care and being in dialogue...

See full abstract

 

Til toppen Program 5 - Health Promotion and Innovation

Sundhedfremme: moralisering eller involvering. Otto, L.

Rather than simply criticising the exercise discourse, the article argues that it also has a positive effect in that it creates space for new body habits and new types of self-awareness and experience of our bodies.

Delineating Disease: drawing insights in the medical museum". Lyons, L.


In research conducted over a five - year period I investigated the role of a method of drawing called delineation as a system for gaining further understanding of a rare congenital disease, Fibrodysplasia Ossificans Progressiva (FOP). Insight was achieved by both those engaged in the drawing process and those viewing the drawings...